NR foda (23111-00-4)

NR foda (23111-00-4) bidiyo

Nicotinamide Riboside chloride (NR) Sfasali

Nicotinamide Riboside Chloride

Jikin ɗan adam wani hadadden tsari ne wanda ya ƙunshi sel, kyallen takarda, da tsarin gabobin jiki. Ana tsara aikin da ya dace na sel da kyallen takarda a cikin jiki kuma suna taimakawa ta hanyar sinadarai, enzymes, da abubuwan gina jiki daban-daban. Wasu daga cikin waɗannan jikin na iya yin kansu, wasu kuma dole ne a sha. Don haka, waɗannan sinadarai suna cikin nau'in abinci da kari. Ɗaya daga cikin waɗannan abubuwan da za su iya taimakawa wajen warkarwa da daidaita jiki shine ake kira nicotinamide riboside chloride (NR). Yana taimakawa wajen ƙara yawan adadin nicotinamide adenine dinucleotide (NAD+) a cikin jiki.

Menene Nicotinamide Riboside Chloride yake yi?

Nicotinamide Riboside Chloride, wanda kuma ake kira NR, shine pyridine nucleoside na bitamin B3. Yana aiki azaman mai gaba ga nicotinamide adenine dinucleotide (NAD+). Yana samuwa azaman mai kashe-fari zuwa kodadde foda mai launin rawaya. Yana daya daga cikin mafi kyawun binciken NAD + kamar yadda yake da yawa amfanin kiwon lafiya. 

NAD+ an haɗa shi don zama ɗayan manyan abubuwan da ke aiki akan nau'ikan hanyoyin homeostasis daban -daban a cikin jiki. Zai iya taimakawa wajen kiyaye lafiyar jiki, haɓaka rayuwar sel, yana taimakawa aiwatar da ayyuka daban -daban na rayuwa da taimako a cikin kula da cututtukan cututtuka daban -daban a cikin jiki. 

NR foda ya nuna inganci azaman magani mai tasowa a cikin cututtuka daban -daban. A manyan allurai, NR na iya magance yanayi kamar cututtukan zuciya, cututtukan neurodegenerative, cututtukan musculoskeletal, da rikicewar rayuwa. An kuma nuna NR yana jinkirta tsufan sel da tsawaita rayuwarsu. Ana samunsa a samfuran abinci kamar kifi, kaji, ƙwai, madara, da hatsi. 

Menene Nicotinamide Riboside Chloride yake yi?

Don fahimtar abin da nicotinamide riboside chloride ke yi, dole ne mu fara fahimtar nicotinamide adenine dinucleotide ko NAD+. 

NAD+ shine coenzyme mai mahimmanci a jikin mutum. Yana aiki a cikin gudanar da hanyoyi daban -daban na rayuwa. Kasancewarsa a cikin jiki ya zama dole don magance nau'ikan cututtukan da yawa. Hakanan yana taimakawa samar da kuzari ga kwakwalwa, ƙwayoyin rigakafi, da tsokoki.

Adadin NAD+ wanda za a iya samu daga tushen abinci yana da ƙima. Wannan bai isa ba don yawancin sel na jiki suyi amfani. Don yin shi, jiki yana shan hanyoyi daban -daban. Akwai manyan hanyoyi guda uku waɗanda NAD+ za a iya haɗa su. Tafarkin kira na De novo, hanyar Preiss Handler, da kuma hanyar Ceto.  

Hanyar Ceto ita ce mafi yawan tsari wanda ake yin NAD + a cikin jiki. A cikin wannan hanyar, NAD + tana fuskantar redox halayen. Ya haɗa da samun raguwa ta hanyar daidaitattun electron biyu, wanda sai ya zama wani nau'i mai suna nicotinamide adenine dinucleotide (NADH). Tunda abin da ake ci kari bai isa ba don buƙatar jiki don NAD +, hanyar ceto yana amfani da sake amfani da NAD da ke akwai da kuma nau'ikan sa daban-daban. 

 Ofaya daga cikin manyan ayyukan da NAD+ ke yi shine kunna sirtuins, ƙungiyar enzymes 7, Sirt1 zuwa Sirt7. Wadannan enzymes suna da aikin sarrafa tsufa da tsawon rai na sel. Sirtuins suna aiki akan matakai da yawa na rayuwa, kamar sakin insulin, tattarawar lipids, da mayar da martani. Har ma yana iya daidaita tsawon rayuwa. Ana kunna Sirtuins lokacin da matakan NAD+ suka tashi. 

NAD+ shima substrate ne ga rukunin sunadaran da ake kira poly ADP-ribose polymerase (PARP). Yana da alhakin gyaran DNA da kwanciyar hankali a cikin kwayoyin halitta kuma yana iya zama alhakin tsawon rayuwa. 

Matakan NAD+ suna raguwa tare da shekaru da cututtuka. Wasu daga cikin dalilan raguwar sa sune kumburi na yau da kullun, ƙara kunna tsarin garkuwar jiki, da rage ayyukan nicotinamide phosphoribosyltransferase (NAMPT), wanda ke haifar da raguwar samarwa. Yayin da jikin ɗan adam ya tsufa, adadin lalacewar DNA yana ƙaruwa tare da ƙaramin damar gyarawa, yana haifar da tsufa da cutar kansa. 

Akwai 'yan hanyoyi don haɓaka matakan matakan NAD+ a cikin jiki. Suna cin abinci kaɗan kuma suna sarrafa adadin adadin kuzari, azumi, da motsa jiki. Waɗannan ayyukan kuma na iya taimakawa wajen kiyaye lafiyar jiki da aiki.

Sauran dabaru don haɓaka NAD + sun haɗa da cinye tryptophan da niacin da shan abubuwan ƙarfafa NAD + kamar nicotinamide riboside chloride da nicotinamide mononucleotide. 

Nicotinamide riboside chloride shine farkon wanda zai iya haɓaka matakan salula na NAD+. Hakanan shine tushen Vitamin B3. Samfuri ne wanda ke aiki akan hanyar ceton NAD+ samarwa. Yana juyawa zuwa nicotinamide mononucleotide (NMN) tare da taimakon enzyme NR kinase Nrk1. Daga nan yana ƙara juyawa zuwa NAD+. 

Bayan bayar da NR, matakan NAD+ suna ƙaruwa a cikin jiki, wanda daga nan aka rarraba shi zuwa sassa daban -daban. Ba zai iya ƙetare shingen kwakwalwa-jini ba, amma yana canzawa zuwa nicotinamide wanda daga nan ake jigilar shi zuwa kwakwalwa da sauran kyallen takarda inda ya samar da NAD+. 

Yawancin bayanai game da ingancin Nicotinamide Riboside chloride sun fito ne daga binciken dabbobi. Binciken ɗan adam har yanzu yana da iyaka kuma ana buƙatarsa ​​sosai.

Amfanin Nicotinamide Riboside Chloride

Akwai fa'idodi da yawa na amfani Nicotinamide Riboside Chloride. Su ne: 

Tasiri akan Cututtukan Neuromuscular

Nicotinamide riboside chloride's ikon haɓaka NAD + na iya haɓakawa ayyukan mitochondria. Wannan na iya taimakawa wajen magance cututtukan cututtukan mitochondrial [1]. NR foda kuma an nuna cewa yana da tasiri wajen inganta ayyukan dystrophy na muscular.

Illolin cututtukan zuciya

Duk wata matsala tare da metabolism na NAD+ na iya haifar da matsaloli tare da zuciya da jijiyoyin jini. Zai iya haifar da yanayi kamar gazawar zuciya, hauhawar matsin lamba, bugun zuciya, da sauransu NR ƙarin na iya kawo ragin NAD + da nicotinamide adenine dinucleotide + hydrogen (NADH) zuwa na al'ada kuma dakatar da sake fasalin mara kyau na ƙwayoyin zuciya [2]. Hakanan yana iya juyar da tasirin bugun zuciya. 

Tasiri akan cututtukan neurodegenerative

Cututtukan Neurodegenerative galibi suna faruwa da tsufa. Suna da alaƙa da damuwar oxyidative wanda zai iya lalata DNA. Yawancin lokaci, za a sami ayyuka marasa kyau na mitochondria, suna bin wasu dalilai bayan ƙwayoyin ba za su iya yin aiki da kyau ba. NAD+ yana raguwa a cikin adadin yayin da jikin ya tsufa, wanda ke haifar da rashin aikin mitochondria. Wannan na iya haifar da cututtukan neurodegenerative daban -daban. Hakanan yana iya haɓaka damar cutar Alzheimer. 

Nicotinamide Riboside chloride yana ƙara adadin NAD + a cikin jiki, yana rage yawan damuwa, kuma yana iya gyara DNA da ta lalace. Hakanan yana taimakawa wajen magance cutar Alzheimer a cikin beraye [3]. Hakanan zai iya rage kumburi a cikin kwakwalwa, yana taimakawa inganta cognition da ƙwaƙwalwar ajiya [4]. Zai iya yin haka ta hanyar rage adadin furotin amyloid-β na farko da kuma hana amyloidogenesis. 

NR foda kuma yana iya dakatar da lalacewar axons a cikin nau'ikan cututtukan cututtukan neurodegenerative ta hanyar canza metabolism na NR a cikin axon [5]. Rushewar ƙwayoyin jijiyoyin da ke karkacewa waɗanda ke ratsa ƙwayoyin gashi na cochlear na iya faruwa bayan fallasa su zuwa matsanancin hayaniya. NR ya nuna yana da tasiri wajen hana asarar ji-hayan. Yana yin hakan ta hanyar yin aiki akan sirtuin ko SIRT3 mai dogara wanda ke rage lalacewar neurite [6].  

Tasiri kan masu ciwon sukari

Nicotinamide ribonucleoside chloride ya nuna yana da tasiri wajen rage alamun cututtukan cuta kamar nau'in ciwon sukari na II [7]. An nuna shi don inganta haƙuri ga glucose, rage nauyi da magance lalacewar hanta a cikin beraye. Don haka yana iya zama mai tasiri wajen kula da mutane ma. 

Tasiri kan lafiyar hanta

An nuna yanayin hanta kamar cutar hanta mai kitse ba ta barasa ba don haifar da rashi NAD+. Don haka, haɓakawa tare da NR foda na iya taimakawa don mafi kyawun farfadowa a cikin waɗannan yanayi [8]. 

Tasiri akan Tsufa 

Hakanan an gano NAD+ yana rage tsufan sel kuma yana rayar da su. Hakanan an gano yana inganta ayyukan ƙwayoyin sel waɗanda suma suna taimakawa rage tsufa [9]. 

Fa'idar Nicotinamide Riboside Chloride akan Sauran NAD+ Masu Gabatarwa

NR yana da ingantaccen bioavailability kuma yana da aminci don amfani idan aka kwatanta da sauran abubuwan ƙaddara. An nuna yana ƙaruwa matakan NAD+ ƙari akan shan baki a cikin beraye kuma yana ba da ƙarin NAD+ a cikin tsokoki idan aka kwatanta da sauran abubuwan ƙaddara. Hakanan yana iya sarrafa matakan lipid na jini mafi kyau kuma yana ƙara matakin NAD+ a cikin zuciya [10]. 

Illolin Side na Nicotinamide Riboside Chloride

Ciwon baki na nicotinamide riboside chloride a cikin ƙananan allurai yana da lafiya. Yana iya haɗawa da wasu illa kamar

• Tashin zuciya
• Ruwan jini 
• Edema
• Itching
• gajiya
• ciwon kai
• zawo
• Upset ciki
• bacin
• Vomiting

Yadda ake Siyan Nicotinamide Riboside Chloride?

Idan kuna son siyan foda NR, zai fi kyau ku tuntuɓi masana'antar kera Nicotinamide Riboside Chloride. Yana tabbatar da cewa ana amfani da mafi kyawun kayan don samarwa, ƙarƙashin kulawar ƙwararrun masana a fagen da ke da alaƙa. Waɗannan samfuran ana yin su ne ta bin ƙa'idodin aminci waɗanda ke tabbatar da cewa samfurin yana da inganci, tare da babban ƙarfi, kuma an haɗa shi da kyau. Dangane da buƙatun mai amfani, ana iya tsara umarnin don dacewa da takamaiman dandano. 

Da zarar an yi samfurin, yana buƙatar a ajiye shi a cikin zafin jiki na 0 zuwa 4C don ɗan gajeren lokaci da -20C na dogon lokaci. Don hana shi lalacewa ko amsawa da wasu sinadarai a cikin muhalli.

References

• Chi Y, Sauve AA. Nikotinamide riboside, mai gina jiki mai gina jiki a cikin abinci, shine bitamin B3 tare da tasiri akan metabolism na makamashi da neuroprotection. Curry Opin Clin Nutr Metab Kulawa. 2013 Nuwamba; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Dubawa. PubMed PMID: 24071780.
• Bogan KL, Brenner C. Nicotinic acid, nicotinamide, da nicotinamide riboside: kimantawar kwayoyin NAD + takamaiman bitamin a cikin abincin mutum. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Dubawa. PubMed PMID: 18429699.
• Ghanta S, Grossmann RE, Brenner C. Mitochondrial sunadarin protein na Mitochondrial a matsayin mai amfani da sikila, masanin juyin halitta na adana mai: sunadarai da dabaru na haɓakar acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nuwamba-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Dubawa. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
• Duk abin da kuke Bukatar Ku sani game da Nicotinamide Riboside Chloride

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