Urolithin foda

Cofftek yana da ikon samar da taro da wadatar urolithin a, urolithin b da Methylurolithin A ƙarƙashin yanayin cGMP.

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Menene Urolithins?

Urolithins abubuwan asali ne ko metabolites na abubuwan acid ellagic kamar ellagitannins. Waɗannan abubuwan sunadarai sun narkar da su daga ellagic acid-derivatives ta hanji microbiota.

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Tun da furen na hanji yana da mahimmanci don samar da urolithins, adadin urolithins da ake samarwa a cikin jiki ya dogara da nau'in ƙwayoyin cuta a cikin flora, mafi mahimmancin kwayoyin mallakar ƙungiyar Clostridium leptum. An ba da rahoton cewa mutanen da ke da ƙwayoyin microbiota masu arziki a cikin membobin wannan rukunin suna samar da adadin urolithins mafi girma fiye da waɗanda ke da sauran ƙwayoyin tsirrai kamar Bacteroides ko Prevotella.
Hakanan ana samar da urolithins daga punicalagin a cikin hanji, kamar ellagitannins, sannan a fitar da shi cikin fitsari. Don bincika samar da urolithin a cikin jiki, ana buƙatar bincika matakan su a cikin fitsarin mutumin da ya cinye abinci mai wadataccen acid ellagic ko kari tare da urolithins a matsayin babban sinadarin su. Urolithin, sau ɗaya a cikin plasma, ana iya gano shi ta hanyar glucuronides.
Ana samun urolithins a cikin abinci da yawa, kodayake ba duk ƙwayoyin urolithins za a iya samu daga abinci ba. Da zarar an ci abinci mai wadataccen acid ellagic, ya dogara da hanjin tsirrai don rushe ellagitannins da punicalagin zuwa cikin metabolites na tsakiya da samfuran ƙarshe; kwayoyin urolithin.
Waɗannan ƙwayoyin kwanan nan sun sami shahara kuma suna ci gaba da haɓaka azaman kayan abinci na abinci saboda rigakafin ƙwayar cuta, tsufa, ƙin kumburi, da fa'idodin haifar da cutar kansa. Haka kuma, takamaiman kwayoyin urolithin suna da alaƙa da ingantattun matakan makamashi yayin da suke da babban tasiri akan lafiyar mitochondrial. Samar da makamashi a cikin jiki tsari ne wanda ke faruwa a cikin mitochondria, kuma haɓaka aikin wannan gabobin yana ɗaya daga cikin ayyuka da yawa na Urolithins.

An san Molecules na Urolithin

Urolithins suna magana gabaɗaya zuwa ƙwayoyin daban daban waɗanda ke cikin dangin urolithin amma suna da tsarin sunadarai daban -daban, sunayen IUPAC, tsarin sunadarai, da tushe. Bugu da ƙari, waɗannan ƙwayoyin suna da fa'ida da fa'ida daban -daban akan jikin ɗan adam kuma saboda haka ana tallata su daban a cikin sigar kari.
Urolithins, after extensive research, is known to breakdown into the following molecules in the body, although not much is known about every specific molecule: ●Urolithin A (3,8-Dihydroxy Urolithin)
Rol Urolithin A glucuronide
Rol Urolithin B (3-Hydroxy Urolithin)
Rol Urolithin B glucuronide
Rol Urolithin D (3,4,8,9-Tetrahydroxy Urolithin)
Urolithin A da Urolithin B, wanda aka fi sani da UroA da UroB bi da bi, sune sanannun metabolites na Urolithins a jiki. Waɗannan biyun kuma sune kwayoyin da ake amfani da su a halin yanzu a cikin abubuwan kari da kayan maye.

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Da zarar cikin jini, Urolithin A yana nan a matsayin Urolithin A glucuronide, kuma ana iya gano Urolithin B azaman Urolithin B glucuronide. Saboda wannan, an yi imanin cewa suna da tasiri iri ɗaya kamar na ƙaddarar su kamar yadda binciken vivo bai yiwu ba tare da urolithins. Rashin nazarin vivo yana da wahala a tantance idan UroA da UroB glucuronides suna da wani tasiri daban da UroA da UroB da kansu.
Urolithin A yana da wani asali wanda za'a iya gano shi cikin jini, wato, Urolithin A sulfate. Duk waɗannan abubuwan da aka samo asali suna yin ayyukansu a cikin jini sannan ana share su daga tsarin ta fitsari.
Urolithin D is another important molecule that is produced by the effects of the gut microbiota, however, not much is known about its effects and potential uses. Currently, it is not being used in any supplements or meal replacements, unlike its counterparts, UroA and UroB. Moreover, dietary sources of Urolithin D are not known

Urolithin Kunshin Bayanin Foda

Ba a samun Urolithin A a zahiri daga tushen abinci kuma yana cikin rukunin mahaɗan da aka sani da benzo-coumarins ko dibenzo-α-pyrones. A zahiri an narkar da shi daga ellagitannins zuwa Urolithin A 8-Methyl Ether kafin a kara rushe shi zuwa Urolithin A. Wannan samfurin na ƙarshe yana samuwa da yawa a masana'antar masana'antar mu ta hanyar Urolithin A foda. MethylUrolithin Hakanan ana samun foda don siye da yawa idan an buƙata.
Ba a samun Urolithin A a cikin matakan guda ɗaya, har ma da irin matakan amfani da masu ƙaddarar sa, a cikin mutane daban -daban saboda duk ya dogara da aikin gut microbiota. An yi imanin metabolism na Urolithin A yana buƙatar Gordonibacter urolithinfaciens da Gordonibacter pamelaeae amma wasu mutanen da ke da waɗannan har yanzu suna nuna kaɗan kaɗan don ba su da tasiri a kan samar da ƙwayoyin.

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Urolithin A yana da takamaiman fasalulluka waɗanda ke sa ya bambanta da sauran abubuwan, kamar waɗanda aka ambata a teburin da ke ƙasa.
CAS Number 1143-70-0
tsarki 98%
IUPAC sunan 3,8-Dihydroxybenzo [c] chromen-6-one
nufin abu ɗaya ne 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-daya; 3,8-DIHYDRO DIBENZO- (B, D) PYRAN-6-DAYA; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-one; Alamar Castoreum I; Urolithin A; 6H-Dibenzo (B, D) pyran-6-daya, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-daya
kwayoyin Formula C13H8O4
kwayoyin Weight 228.2
Ƙaddamarwa Point > 300 ° C
InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N
Form m
Appearance Haske Yellow foda
Half-Life Ba a sani ba
solubility Matsala a cikin DMSO (3 mg / mL).
Storage Yanayin Kwanaki zuwa Makwanni: A cikin duhu, dakin bushewa a 0 -4 digiri C Watanni zuwa Shekaru: A cikin injin daskarewa, nesa da ruwa a -20 digiri C.
Aikace-aikace Ana amfani da abinci azaman maye gurbin abinci da kari

Kunshin Bayanai na Urolithin B

Urolithin B wani sinadarin phenolic ne wanda aka fara samar da shi da yawa tun daga watan Janairu na 2021. Ana iya samunsa ta hanyar cin abinci da yawa waɗanda tushen asalin ellagitannins ne waɗanda za a iya narkar da su cikin Urolithin B. An gano cewa yana da ƙarfi fili mai tsufa wanda zaku iya siyan sa a cikin nau'in Urolithin B foda.

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Daban -daban kaddarorin Urolithin B foda da ake samu a kamfanin masana'antar mu an ambaci su a ƙasa:
CAS Number 1139-83-9
tsarki 98%
IUPAC sunan 3-Hydroxy-6H-dibenzo [b, d] pyran-6-daya
nufin abu ɗaya ne AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo [c] chromenone; 3-hydroxybenzo [c] chromen-6-daya; 3-Hydroxy-benzo [c] chromen-6-daya; 3-HYDROXY-6H-DIBENZO [B, D] PYRAN-6-DAYA; 6H-Dibenzo (b, d) pyran-6-one, 3-hydroxy-; 3-Hydroxy-6H-benzo [c] chromen-6-one AldrichCPR
kwayoyin Formula C13H8O3
kwayoyin Weight 212.2 g / mol
Ƙaddamarwa Point > 247 ° C
InChI Key WXUQMTRHPNOXBV-UHFFFAOYSA-N
Form m
Appearance Haske launin ruwan kasa
Half-Life Ba a sani ba
solubility Mai narkewa a 5mg/ml lokacin dumama, ruwa mai tsabta
Storage Yanayin 2-8 ° C
Aikace-aikace Anti-oxidant da Pro-oxidant kari tare da aikin estrogenic.
Baya ga waɗannan manyan ƙwayoyin Urolithins waɗanda aka kirkira sakamakon ayyukan gut flora, akwai ƙwayoyin da yawa waɗanda masu tsaka -tsaki ne waɗanda aka kirkira yayin ɓarkewar masu ƙaddara. Waɗannan tsaka -tsakin sun haɗa da:

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Rol Urolithin M-5
Rol Urolithin M-6
Rol Urolithin M-7
Rol Urolithin C (3,8,9-Trihydroxy urolithin)
Rol Urolithin E (2,3,8,10-Tetrahydroxy urolithin)
Ba a san abubuwa da yawa game da waɗannan tsaka -tsakin ba kamar yanzu, duk da haka, ƙarin bincike yana da yuwuwar gano fa'idodi da amfani da waɗannan ƙwayoyin Urolithin.
 

Ta yaya Urolithins ke Aiki?

Urolithins, kamar sauran mahaɗan da ake amfani da su a cikin kari, suna shafar gabobi da tsarin jiki daban -daban, don samar da tasirin su. Injin aikin Urolithins, duka A da B, ana iya raba su zuwa manyan rassa shida, kuma kowane reshe yana da yuwuwar samar da fa'idodi da yawa.
Ties Antioxidant Properties
Babban fa'idar samun kaddarorin antioxidant shine rage danniya a cikin jiki. Damuwar Oxidative tana nufin damuwa akan sel da kyallen takarda a cikin jiki sakamakon halayen sunadarai waɗanda ke samar da mahadi mara tsayayye, wanda kuma aka sani da tsattsauran ra'ayi. Waɗannan tsattsauran ra'ayi suna da ƙarin damar shiga cikin halayen sunadarai masu rikitarwa a cikin jiki, samfuran da ke lalata sel da kyallen takarda.
Urolithins suna murƙushe wannan danniya na oxyidative, wanda ke haifar da hana raunin sel kuma yana haɓaka damar rayuwa. Ana yin waɗannan tasirin ta hanyar rage samar da ƙwayoyin Oxygen Speactive Reactive (iROS), waɗanda sune nau'ikan tsattsauran ra'ayi. Haka kuma, kaddarorin antioxidant na Urolithin A da Urolithin B suma suna tasowa ta hanyar rage NADPH oxidase subunit magana, wanda yake da mahimmanci ga halayen sunadarai wanda ke haifar da danniya mai cutarwa.

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Don samar da kaddarorin antioxidant, Urolithins kuma suna haɓaka bayyanar antioxidant heme oxygenase-1 ta hanyar alamar Nrf2/ARE. Wannan yana taimaka musu ba wai kawai rage mahadi masu cutarwa ba amma kuma suna haɓaka kyawawan enzymes waɗanda ke haɓaka kaddarorin antioxidant.
Urolithins, lokacin da aka ba wa beraye tare da lalacewar kwakwalwa ta LPS, sun hana kunna microglial, ko a cikin mafi sauƙi, tabo da samuwar kumburi wanda zai ƙara haɗarin lalacewar kwakwalwa ta dindindin. Anyi imanin wannan tasirin urolithins shine cakuda kaddarorin antioxidant da kaddarorin kumburi.
● Abubuwan Anti Inflammatory
Kayayyakin kumburin kumburin Urolithins suna ɗaya daga cikin manyan dalilan da ya sa ake samun ƙaruwa a cikin duniyar kari. Hanyar da waɗannan mahaɗan, musamman Urolithin A, Urolithin B, da nau'in glucuronides ɗin su, sun sha bamban kuma suna haifar da sakamako iri ɗaya daidai.
Sakamakon anti-inflammatory na Urolithin A da Urolithin B yana da tsari iri ɗaya kamar Magungunan Anti-Steroidal Anti-inflammatory ko NSAIDs kamar Ibuprofen da Aspirin. An san Urolithins suna da tasirin hanawa akan samar da PGE2 da bayyanar COX-2. Kamar yadda NSAIDs ke hana bayyanar duka COX 1 da COX 2, ana iya yanke shawarar cewa Urolithins suna da ƙarin zaɓin maganin kumburi.
An tabbatar da kaddarorin anti-inflammatory na Urolithins ba wai kawai suna yaƙar kumburi a cikin jiki ba amma kuma suna iya jujjuya lalacewar da aka yi wa gabobin sakamakon kumburin na dogon lokaci wanda ya haifar da gazawar gabobin. A cikin binciken da aka yi kwanan nan akan samfuran dabbobi, an gano cewa amfani da urolithin yana da ikon rage nephrotoxicity da ke haifar da miyagun ƙwayoyi ta hanyar hana mutuwar ƙwayar koda da kumburi.

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An gano cewa urolithin A foda, wanda aka bayar da baki, yana da tasirin hanawa akan hanyar kumburi tare da proapoptotic cascade, saboda haka, yana kare aikin koda. Waɗannan kaddarorin Urolithin A tare da sauran urolithins suna nuna makoma inda za'a iya amfani da waɗannan mahaɗan a magani tare da amfani da su na yanzu azaman kari.
Ties Abubuwan Anti-Carcinogenic
An yi imani da cewa Urolithins anti-carcinogenic ne saboda ikon su na samun tasiri kamar kamawar sake zagayowar sel, hana aromatase, shigar apoptosis, murƙushe ƙari, haɓaka autophagy, da tsufa, ƙa'idar rikodin oncogenes, da masu karɓar abubuwan haɓaka. Waɗannan tasirin, idan ba su nan, na iya haifar da haɓakar haɓakar ƙwayoyin kansa. An tabbatar da fasalulluka na rigakafin Urolithins, musamman don cutar sankara ta prostate da kansar hanji, tare da masu bincike da yawa sun haɗu don amfani da Urolithins a matsayin yuwuwar rigakafin cutar kansa.
Nazarin da aka yi a cikin 2018 yayi nazarin tasirin Urolithin akan hanyar mTOR da nufin nemo zaɓin magani don cutar kansa. Ana alakanta cutar kansa da yawan mace -mace, amma bincike na baya -bayan nan ya nuna cewa Urolithin na iya haɓaka ba kawai ƙara yawan rayuwa ba amma kuma yana hana haɓakar ƙwayoyin ƙwayar cuta zuwa wasu sassan jiki, wanda ke haifar da metastasis. Anyi nazarin Urolithin A musamman kuma an kwatanta sakamakon da sakamakon da daidaitaccen tsarin kulawa ya samar. An kammala cewa Urolithin A ya samar da kyakkyawan sakamako lokacin da aka yi amfani da shi don gudanar da cutar kansa ta hanji, a cikin duka yanayin; lokacin amfani da shi kadai ko tare da daidaitaccen shirin jiyya.
Tare da ƙarin bincike, fa'idodin Urothilins na iya ƙunsar maganin ciwon daji na hanji.
Abubuwan Antibacterial Properties
An san Urolithins saboda kaddarorin su na ƙwayoyin cuta kuma suna da wannan tasirin ta hana tashoshin sadarwa na ƙananan ƙwayoyin cuta, ba da damar su motsawa ko kamuwa da sel. An kuma yi imanin cewa suna da kaddarorin antifungal, kodayake ba a fayyace ainihin injin ba.
Akwai ƙwayoyin cuta guda biyu waɗanda Urolithins ke da tasirin hana ƙarfi musamman, wanda ke haifar da kariya ga jikin ɗan adam. Waɗannan cututtukan ƙwayoyin cuta sune ƙwayoyin cuta na zazzabin cizon sauro da Yersinia enterocolitica, tare da su duka suna haifar da mummunan cututtuka a cikin mutane. Hanyar da Urolithins ke da kaddarorin ƙwayoyin cuta ba tare da la’akari da kwayoyin halitta iri ɗaya ba ne.
Anti Estrogenic da Estrogenic Properties
Estrogen wani muhimmin hormone ne a cikin jikin mace, kuma raguwar matakan sa yana da alaƙa da alamomi kamar flushing, walƙiya mai zafi, da raguwar ƙashi. Ganin mahimmancin hormone, yana da ma'ana cewa ana neman mai maye gurbin. Koyaya, hormones na waje suna da wasu illa masu illa waɗanda ke sa amfanin su ba a so.

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Koyaya, Urolithin A da Urolithin B suna da tsari iri ɗaya kamar isrogen endogenous da kusanci ga masu karɓar isrogen a cikin jiki. Urolithin A yana da alaƙa mai ƙarfi, musamman ga mai karɓar alpha idan aka kwatanta da mai karɓar beta. Kodayake duka waɗannan mahaɗan suna da kamanceceniya na tsari tare da estrogen, urolithins suna da kaddarorin estrogenic da anti-estrogenic, sabanin isrogen mai ƙarewa.
Duality na wannan tasirin Urolithins yana sanya su zaɓin magani mai yuwuwar don wasu rikice -rikicen da ke tasowa lokacin da aka ba da isrogen mai yawa don magance alamun ƙarancin isrogen.
Rinjaye Glycation Inhibition
Glycation na furotin tsari ne wanda aka ɗaure ƙwayar sukari zuwa furotin. Ana ganin wannan tsari yayin tsufa ko kuma wani ɓangare na wasu cuta. Urolithins suna hana haɓaka sukari, saboda haka yana haifar da tasirin anti-glycation. Haka kuma, suna hana ci gaban samfuran glycation na ci gaba, tarawa wanda shine muhimmin mataki na ilimin pathophysiological a cikin haɓaka ciwon sukari.
 

Amfanin Urolithins

Urolithins suna da dabaru daban -daban na aiki don samar da fa'idodi daban -daban na kariya a jikin ɗan adam. Urolithin A foda da Urolithin B foda suna taimakawa kera abubuwan kari waɗanda suka shahara saboda fa'idodin manyan abubuwan. Duk fa'idodin waɗannan mahaɗan sunadarai suna tallafawa da shaidar kimiyya, har ma ana yin ƙarin bincike don tallafawa ƙarin Urolithins a cikin jagororin don magance rikice -rikice da yawa.
Amfanin waɗannan mahadi, dangane da hanyoyin da aka ambata a sama, sun haɗa da:
Ties Antioxidant Properties
Ana fitar da urolithins daga yawancin abinci masu wadatar ellagitannins waɗanda aka san su da wadatar antioxidants. Mafi yawan abincin abinci na ellagitannins da ellagic acid shine rumman, kuma su ma babban tushen antioxidants ne. Koyaya, yana da mahimmanci a rarrabe idan kaddarorin antioxidant na tushen abinci da urolithins iri ɗaya ne ko kuma idan ɗayan yana da babban ƙarfi fiye da ɗayan.
Nazarin farko na Urolithin A da Urolithin B sun nuna cewa tasirin antioxidant na waɗannan ya ninka sau 42 fiye da na 'ya'yan itacen da kansa, saboda haka yana nuna cewa waɗannan mahaɗan sunadarai ba za su yi abubuwa masu kyau don kari ba.
Koyaya, binciken da aka yi kwanan nan tare da hanyar bincike daban -daban ya nuna cewa Urolithin A da B duka suna da inganci sosai kuma suna da kaddarorin antioxidant masu ƙarfi waɗanda zasu magance tasirin damuwar oxyidative. Lokacin da aka yi amfani da irin wannan hanyar bincike don yin nazarin duk urolithins don ganin wanene ya fi ƙarfin, Urolithin A ya yi fice. Daga nan aka sake buga sakamakon a cikin irin wannan binciken tare da Urolithin A wanda ke jagorantar iko, kuma.

(9)↗

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A zahiri, ɗayan binciken ya mai da hankali kan kimanta kaddarorin antioxidant na waɗannan mahaɗan sunadarai ta hanyar gwada ikon su na yaƙar danniyar oxyidative. Don manufar wannan binciken, masu bincike sun haifar da damuwa a cikin ƙwayoyin neuronal kuma lokacin da aka fallasa su ga Urolithins, musamman Urolithin B, sun lura da raguwar damuwa a cikin damuwa tare da ƙara yawan tsira na ƙwayoyin jijiyoyin.
● Abubuwan Anti Inflammatory
Abubuwan da ke hana kumburi na Urolithins suna haifar da fa'idodi da yawa, duk an tabbatar da su a kimiyance.
1.Antimalarial sakamako
Magani na gida don maganin zazzabin cizon sauro wanda aka fi amfani da shi a wasu yankunan karkara ya ƙunshi amfani da Rumman. Masu bincike sun yi ƙoƙarin fahimtar kyakkyawan tasirin wannan maganin akan maganin zazzabin cizon sauro ta hanyar haɗa sakamakon tare da tasirin Urolithins metabolized a cikin hanji daga rumman.
An gudanar da bincike don yin nazarin tasirin Urolithins a cikin maganin zazzabin cizon sauro ta hanyar fallasa ƙwayoyin monocytic masu kamuwa da cuta ga Urolithins. Wannan binciken ya gano cewa mahaɗan sunadarai sun hana sakin MMP-9, wanda shine muhimmin metalloproteinase a cikin ci gaba da cututtukan cututtukan zazzabin cizon sauro. Karkatar da mahallin yana hana zazzabin cizon sauro daga kamuwa da cuta a cikin jiki, saboda haka yasa aka yi imanin yana da tasirin cutar zazzabin cizon sauro.
Sakamakon binciken ya kuma nuna cewa Urolithins sun hana bayyanar mRNA na cututtukan zazzabin cizon sauro, wanda hakan ke haifar da ƙarin hana ƙwayoyin ƙwayoyin cuta don haifar da kamuwa da cuta. Sakamakon wannan binciken ya tabbatar da cewa fa'idoji masu fa'ida na magunguna na gida ciki har da rumman ya kasance sakamakon tasirin urolithin.
2.Yana tasiri akan Kwayoyin Endothelial
Atherosclerosis wani yanayi ne na yau da kullun wanda ke haifar da zagi na zuciya da bugun zuciya. Abubuwa biyu na gama gari da ke haifar da ci gaban atherosclerosis sune lalacewar endothelial da kumburi. Nazarin kwanan nan sun yi ƙoƙarin tabbatar da cewa kaddarorin anti-inflammatory na Urolithin na iya samun damar hana lalacewar endothelial, don haka, sarrafa sarrafa atherosclerosis da haɓakawa.
Masu binciken sun gano Urolithin A yana da mafi girman aikin hana kumburi tsakanin dukkan urolithins. Binciken da aka yi kwanan nan ya mai da hankali kan ƙwayoyin endothelial ɗan adam waɗanda aka haɗa su da LDL oxidized, abin da ake buƙata don samuwar atherosclerosis, da yawa daban-daban na Urolithin A. Masu binciken sun gano cewa Urolithin A ya hana nitric oxide synthase kuma ya rage bayyanar I-CAM, wanda ya haifar da rage kumburi da raguwar ikon sel, musamman monocytes don biyewa sel endothelial, bi da bi. Rage riko da monocytic yana rage lalacewar endothelial.
Bugu da ƙari, an sami Urolithin A don rage bayyanar ƙwayar necrosis factor α, interleukin 6, da endothelin 1; duk cytokines pro-inflammatory.
3.Yana tasiri akan Fibroblasts a cikin hanji
Colon yana fuskantar cututtukan ƙwayoyin cuta da abubuwan haɗin abinci waɗanda ke sa shi saurin kamuwa da kumburi, wanda a ƙarshe zai iya haifar da lamuran kiwon lafiya da yawa. Kamar yadda Urolithin A da Urolithin B ke tsirowa ta hanyar tsirrai na hanji, yana da mahimmanci a san tasirin su tun farko a jikin da aka ƙera su.
Don nazarin tasirin Urolithins akan ƙwayoyin hanji da fibroblasts, masu bincike sunyi gwajin inda fibroblasts suka fallasa cytokines masu kumburi sannan ga Urolithins. Kamar yadda aka ambata a sama, an gano cewa Urolithins yana hana haɗewar monocyte da ƙaurawar fibroblast don hana kumburi a cikin hanji.
Haka kuma, an gano cewa Urolithins sun hana kunna NF-κB factor, wanda yake da mahimmanci don daidaita kumburi. A zahiri, masu bincike sun yi imanin wannan shine babban abin da ke haifar da kumburin urolithins.
Ties Abubuwan Anti-Carcinogenic
Urolithins suna da alaƙa da kaddarorin cutar kansa, kuma an ambaci tsarin waɗannan kaddarorin a sama. Koyaya, an ambaci fa'idodin waɗannan kaddarorin a ƙasa:
1.Karewa daga Ciwon Kankara
Gano Urolithins a cikin jiki galibi ana yin shi ta amfani da jini ko fitsari; duk da haka, ana iya gano su a cikin mazajen maza da mata da kuma glandan prostate na maza.
A sakamakon wannan binciken, masu bincike sun yi ƙoƙarin tantancewa idan ana ganin fa'idojin mahaɗan sunadarai a cikin ƙoshin prostate kamar a cikin hanji. Don haka, an ƙera wani bincike, wanda sakamakonsa ya tabbatar da cewa Urolithins suna da tasirin kariya akan glandan prostate.
An gano cewa Urolithin A da Urolithin B, tare da Urolithin C da Urolithin D sun hana CYP1B1 enzyme a cikin glandan prostate. Wannan enzyme shine makasudin chemotherapy kuma Urolithin A ya hana shi sosai, idan aka kwatanta da sauran urolithins. Sun kuma hana CYP1A1, duk da haka, ana buƙatar babban taro na urolithins don samar da wannan tasirin.
An sake yin wani binciken don nazarin tasirin kariya na prostate na Urolithins. An gano cewa Urolithin A yana da tasirin cutar kansa akan cutar kansa ta hanyar duka, dogaro da p53 da p53 mai zaman kansa.
2.Topoisomerase 2 da CK 2 hanawa
Urolithins suna da kaddarorin cutar kansa ta hanyar hana hanyoyi da yawa na ƙwayoyin cuta wanda kai tsaye ko a kaikaice ke haifar da hana ci gaban cutar kansa. Enzyme CK2 muhimmin enzyme ne wanda ke shiga cikin irin waɗannan hanyoyin kwayoyin, tare da babban aikinsa shine haɓaka ƙonewa da cutar kansa.
Urolithins suna hana hanyoyi daban-daban don isa ga enzyme na kowa, CK2 don ƙarshe ya hana tasirin sa, kamar kaddarorin sa na inganta cutar kansa. An nuna Urolithin A ya zama mai hana CK2 mai ƙarfi, a cikin silico.
Hakanan, Topoisomerase 2 hanawa ana tsammanin yana da tasirin cutar kansa. A zahiri, wasu injunan chemotherapy suna amfani da wannan injin kamar Doxorubicin. A cikin binciken da aka yi kwanan nan, an gano cewa Urolithin A ya fi Doxorubicin ƙarfi wajen hana Topoisomerase 2, saboda haka, yana kira da a ƙara ƙa'idodin jagororin na yanzu don maganin wasu cututtukan daji.
Abubuwan Antibacterial Properties
Abubuwan antibacterial na Urolithins sun dogara ne akan Ingancin Sensing Quorum wanda ke ɗauke da ikon microorganism don sadarwa, motsawa, da ƙirƙirar abubuwan cutarwa. Yana da mahimmin tsari don rayuwar ƙwayoyin cuta, kuma hanawa ta Urolithins yana da haɗari ga ƙwayoyin cuta.
Babban kaddarorin antibacterial na Urolithin shine ikon sa na kare hanji daga haɓakar Yersinia enterocolitica. A zahiri, Urolithins suna da alaƙa da daidaitawar flora na gut, iri ɗaya wanda ke da alhakin samar da su da fari. Wannan yana da mahimmanci musamman saboda takamaiman ƙwayoyin cuta a cikin flora na iya haɓaka samar da Urolithins.
Anti Estrogenic da Estrogenic Properties
Urolithins suna ɗaure ga masu karɓar Estrogen kuma suna samar da duka, kaddarorin estrogenic da anti-estrogenic. Wannan ya sa ya zama babban ɗan takara don Zaɓuɓɓukan Maɓallan Maɓallan Maɓalli na Estrogen ko SERMs, babban maƙasudin su shine samun sakamako mai kyau a wani yanki na jiki da tasirin hanawa a ɗayan ɓangaren jikin.
A cikin ɗayan binciken da aka yi akan tasirin urolithins akan masu karɓar isrogen, an gano cewa su, musamman urolithin A, suna hana bayyanar jigon kwayoyin cutar kansa na endometrial ER-tabbatacce, wanda ke haifar da kawar da ciwon daji na endometrial. Hawan hawan jini na endometrial sakamako ne na gama gari na isrogen mai girma a cikin post neoplasia kamar matan da ke shan maganin maye na hormone, kuma an yi imanin amfani da urolithins yana da tasirin kariya akan endometrium. Koyaya, ana buƙatar ƙarin bincike kafin Urolithins su iya zama maganin SERM na gaba.
Rinjaye Glycation Inhibition
Kasancewar samfuran ƙarshen glycation na ci gaba alama ce ta hyperglycemia wanda ke haifar da mutane ga cututtukan zuciya da ke da alaƙa da ciwon sukari ko ma cutar Alzheimer. An nuna Urolithin A da Urolithin B suna da tasirin anti-glycation wanda ke hana zagi na zuciya da rage haɗarin neurodegeneration sosai.

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Don haka, hana glycation na furotin ta Urolithins an yi imanin yana da tasirin jijiyoyin jini da na jijiyoyin jiki.

An ambaci fa'idodin Urolithin A musamman a ƙasa:

Ƙara tsawon rayuwa
Tsofaffi, damuwa, da wasu rikice -rikice na iya lalata mitochondria, wanda yake da mahimmanci don samar da makamashi na yau da kullun da amfani a cikin jiki. Haka kuma, mitochondria galibi ana kiran su da 'gidan wutar lantarki', wanda ke nuna mahimmancin sa ga aikin sel. Don haka, duk lalacewar wannan gidan wutar lantarki zai yi mummunan tasiri akan tantanin halitta kuma zai rage tsawon rayuwarsa sosai.

(11)↗

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Urolithins suna haifar da takamaiman sakamako da aka sani da mitophagy wanda ke ba da damar jiki ya cire mitochondria da ya lalace, ba tare da la’akari da dalilin lalacewar ba, da haɓaka tsawon rayuwa. Dangane da girman lalacewa, ana iya sake yin amfani da mitochondria don abubuwan gina jiki da samar da makamashi.
● Neuroprotective
Kamar yadda aka ambata a sama, urolithins suna da kaddarorin kumburi kuma waɗannan kaddarorin ne ke haɓaka samuwar ƙwayoyin neuronal a cikin kwakwalwa, wanda ke da tasiri mai kyau akan sani da riƙe ƙwaƙwalwar ajiya. Haka kuma, Urolithin A yana kare kariya daga cututtukan jijiyoyin jiki da aka gani tare da cutar Alzheimer, saboda haka, tasirin neuroprotective.
Hana Ciwon Kankara
Urolithin A yana da kaddarorin rigakafin cutar kansa amma ana ganin su musamman a yanayin cutar kansa, tare da bincike da yawa da ke inganta amfani da rumman da sauran hanyoyin Urolithins don maganin cutar sankara.
Magani Kiba
Urolithin A yana da tasirin rigakafin kiba saboda ba wai kawai yana hana tarin kitse a cikin jiki ba amma yana hana alamomin da ke da alhakin adipogenesis. A cikin binciken da aka yi akan samfuran dabbobi, an gano cewa Urolithin A yana da tasirin haɓakawa akan T3 thyroid hormone, wanda ke haifar da ƙara yawan kuzarin makamashi a cikin beraye. Wannan yana haifar da thermogenesis kuma yana haifar da kitse mai launin ruwan kasa ya narke, yayin da ake jawo fararen mai zuwa launin ruwan kasa.

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A cikin wannan binciken, an gano cewa URolithin A yana da tasirin rigakafin kiba koda a cikin beraye waɗanda aka ciyar da abinci mai kitse. Wannan yana nuna babban alkawari dangane da kiba kuma masu binciken sun yi kira ga aikace -aikacen ɗan adam na waɗannan binciken don samun damar amfani da wannan rukunin don yaƙar cutar kiba.

Fa'idodin Urolithin B sune kamar haka:

Hana asarar tsoka
Urolithin B yana raba wasu fa'idodin Urolithin A amma yana da takamaiman fa'ida guda ɗaya, ta musamman ga kanta. An san Urolithin B don hana asarar tsoka a cikin jihohin ilimin lissafi da na jijiyoyin jini. Bugu da ƙari, yana haɓaka haɓakar ƙwayar tsoka ta hanyar haɓaka haɓakar furotin a cikin tsokoki.

(13)↗

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Hakanan yana da tasirin rigakafin atrophy na tsoka kamar yadda aka gani a cikin binciken da aka yi akan beraye waɗanda suka yanke jijiyar sciatic. Wannan zai haifar da atrophy na tsoka amma an dasa mice tare da ƙaramin famfunan osmotic waɗanda ke ci gaba da ba su Urolithin B. An gano cewa waɗannan mice suna da hanyar su ta ubiquitin-proteasome, wanda hakan ya haifar da rashin ƙarancin atrophy na tsoka duk da sashin jijiya na jijiya. .
 

Sashi na Urolithins

Urolithins an samo su ne daga mahaɗan halitta kuma ana ɗaukar kariyar su da jurewa ba tare da mai ba da rahoto na guba ba. Koyaya, yana da mahimmanci a tuna cewa waɗannan mahaɗan har yanzu suna ƙarƙashin bincike kuma suna da iyakokin sashi wanda yakamata a bi sosai.
Rol Urolithin A.
Bayan bincike mai zurfi kan fa'idojin Urolithin A, an yi binciken bincike da yawa da aka yi don tantance madaidaicin sashin wannan sinadarin. An gudanar da binciken Absorption, Digestion, Metabolism, da Cirewa don nazarin fasali na fili.
An raba binciken zuwa biyu, gwargwadon adadin kwanakin, kuma an gano cewa binciken na kwanaki 28 tare da 0, 0.175, 1.75, da 5.0% na Urolithin A gauraye a cikin abinci da nazarin kwana 90 tare da 0, 1.25, 2.5, da 5.0% Urolithin Haɗuwa a cikin abincin bai nuna canje -canje a cikin sigogi na asibiti ba, sunadarai na jini, ko ilimin cututtukan jini, kuma bai nuna takamaiman hanyoyin guba ba. Duk karatun biyu sun sami mafi girman adadin da aka gwada a 5% UA ta nauyi a cikin abincin wanda ya haifar da allurai masu zuwa; 3451 mg/kg BW/rana a cikin maza da 3826 mg/kg BW/rana a cikin mata a cikin nazarin kwanaki 90.
Urolithin B.
Mai kama da Urolithin A, an yi nazarin Urolithin B sosai don tantance cikakkiyar sashi. Kodayake yana da mahimmanci a lura cewa karatun ya mai da hankali kan amintaccen sashi don cimma ingantaccen ƙwayar tsoka. An gano wannan kashi ya zama 15uM, ga duka jinsi, ba tare da la'akari da nauyi ba.
Rol Urolithin A 8-Methyl Ether
Hakanan ana amfani da wannan fili, galibi saboda shine tsaka -tsaki yayin samarwa Urolithin A. Koyaya, ba a yi isasshen bincike don ƙimar da ta dace don ƙaddara don wannan takamaiman Urolithin ba.
 

Tushen Abincin Urolithins

Ba a samun urolithins a zahiri a cikin kowane tushen abinci, duk da haka, ana samun su azaman ellagitannins. Waɗannan tannins sun rushe zuwa acid ellagic, wanda ke ƙara haɓaka cikin Urolithin A 8-Methyl ether, sannan zuwa Urolithin A, kuma a ƙarshe, Urolithin B. Abincin da ke da wadataccen Urolithins sune:
Tushen abinci Acid Acid
'Ya'yan itãcen marmari (mg/100g sabo nauyi)
Bishiyar Gashi 150
Black raspberries 90
Boysenberries 70
Cloudberries 315.1
rumman > 269.9
Rasberi 270
Rose hip 109.6
strawberries 77.6
Jam Strawberry 24.5
Yellow raspberries 1900
Kwayoyi (mg/g)
Pecans 33
Walnuts 59
Abin sha (mg/L)
Ruwan Rumman 811.1
Cognac 31-55
Oak-old ja ruwan inabi 33
Wuski 1.2
Tsaba (mg/g)
Black raspberries 6.7
Red raspberries 8.7
Boysenberries 30
Mango 1.2
Kamar yadda aka gani a teburin, Cloudberries sune 'ya'yan itacen da mafi girman Ellagitannins da Ellagic acid, tare da Rumman a matsayin na biyu na kusa. Ruwan Rumman, duk da haka, a zahiri shine mafi ƙarfin tushe, kusan sau uku yana da ƙarfi kamar Cloudberries.
Yana da mahimmanci a lura cewa abun cikin ellagic acid a cikin albarkatun abinci bai daidaita adadin urolithin a jiki ba. Halittar bioavailability na URolithins ya dogara sosai akan microbiota gut na kowane mutum.
 

Me yasa yakamata ku saya daga masana'antar masana'antar mu?

Ana samun Urolithin Foda A da Urolithin Foda B da yawa, a masana'antar masana'antar mu wacce ke haɗa samarwa, bincike, haɓakawa, da siyar da irin waɗannan abubuwan kari. Ana ƙera samfuranmu ta amfani da madaidaiciyar madaidaiciya don bin duk jagororin aminci, wanda ke tabbatar da babban inganci da amincin samfurin ƙarshe. Ana bincika duk samfuran kafin a ƙera su kuma ana gwada su sosai a lokacin da bayan samarwa don cika ƙimar ku.
Bayan samarwa, ana gwada samfuran a dakunan gwaje -gwajenmu sau ɗaya don bincika inganci, ƙarfi, da amincin foda Urolithin da sauran samfuran. Da zarar an shirya don rarrabawa, an cika samfuran kuma an adana su a wuraren da suka dace, a madaidaicin zafin jiki yayin bin duk jagororin don tabbatar da cewa samfur mai inganci ya isa gare ku. Urolithin foda ba a fallasa shi zuwa hasken rana yayin jigilar kaya, marufi, ko ajiya saboda hakan na iya lalata samfurin ƙarshe.

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Siyan Urolithin A foda da Urolithin B foda daga masana'antar masana'antar mu tana ba da garantin samfuri mai inganci a farashi mai araha.

Menene Urolithin A?

Urolithin A (UA) is produced endogenously by human gut bacteria exposed to dietary polyphenolic compounds that include ellagic acid (EA) and ellagitannins (ET), such as punicalagin. These polyphenolic precursors are found widely in fruits (pomegranate and certain berries) and nuts (walnuts and pecans).

How does Urolithin a work?

Urolithin A (UA) Is a Gut Microbiome-Derived Compound with Health Benefits for Aging and Diseases. Several dietary products contain the natural polyphenols ellagitannins (ETs) and ellagic acid (EA). ... Once absorbed, UA positively impacts mitochondrial and cellular health in age-related conditions and diseases.

What fruits contain Urolithin A?

Tushen ellagitannins sune: rumman, kwayoyi, wasu 'ya'yan itace (raspberries, strawberries, blackberries, cloudberries), shayi, inabin muscadine,' ya'yan itatuwa masu yawa na wurare masu zafi, da ruwan inabi mai shekaru-shekaru (tebur da ke ƙasa).

What is Urolithin a used for?

The gut microbiota metabolizes ellagic acid resulting in the formation of bioactive urolithins A, B, C, and D. Urolithin A (UA) is the most active and effective gut metabolite and acts as a potent anti-inflammatory and anti-oxidant agent.

What is Urolithin a good for?

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

What foods contain Urolithin A?

Dietary sources of urolithin A
So far, research has found that pomegranate, strawberries, blackberries, camu-camu, walnuts, chestnuts, pistachios, pecans, brewed tea, and oaken barrel-aged wines and spirits contain ellagic acid and/or ellagitannins.

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What are the benefits of Urolithin A?

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging.

How do we get Urolithin A from our diets?

Urolithin A (UA) is produced endogenously by human gut bacteria exposed to dietary polyphenolic compounds that include ellagic acid (EA) and ellagitannins (ET), such as punicalagin. These polyphenolic precursors are found widely in fruits (pomegranate and certain berries) and nuts (walnuts and pecans).

What is Mitopure?

Mitopure is a proprietary and highly pure form of Urolithin A. It helps our bodies counter age-associated cellular decline by revitalizing the power generators inside of our cells; i.e. our mitochondria. ... Urolithin A improves mitochondrial and muscle function, providing more energy to cells.

Is Mitopure safe for human consumption?

In addition, in human clinical studies Mitopure was determined to be safe. (Singh et al, 2017). Mitopure has also been favorably reviewed by the U.S. Food and Drug Administration (FDA) following a GRAS (generally recognized as safe) filing.

When should I take Mitopure?

We recommend taking two Mitopure softgels a day for optimal results. While you can take Mitopure any time of day, we recommend taking it with breakfast, as that is the protocol we used in our clinical trials.

What is Urolithin a supplement?

Urolithin A (UA) Is a Gut Microbiome-Derived Compound with Health Benefits for Aging and Diseases. Several dietary products contain the natural polyphenols ellagitannins (ETs) and ellagic acid (EA). Upon ingestion of such foods, ETs and EA are metabolized into UA by the microflora in the large intestine.

Urolithin A supplement benefits

Urolithin A improves mitochondrial and muscle function, providing more energy to cells. It is a naturally-occurring anti-aging compound that can benefit anyone looking to proactively maintain muscle health.

What is Urolithin B?

Urolithin B shine sinadarin urolithin, wani nau'in mahadi ne da ake samarwa a cikin kwayar dan adam bayan shan kwayar ellagitannins wacce ke dauke da abinci irin su rumman, huda, shukakkun ja, walnuts ko giya mai tsufa. Ana samun Urolithin B a cikin fitsari a cikin sinadarin urolithin B glucuronide.

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Urolithin A supplement benefits

Urobolin is a supplement that comes from punica granatum (Pomegranate) that is standardized to Urolithin B. Urobolin as a supplement can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet.
 

reference:

  1. Totiger TM, Srinivasan S, Jala VR, et al. Urolithin A, Hadaddiyar Labarin Halittu don Target PI3K/AKT/mTOR Pathway a Ciwon daji na Pancreatic. Mol Ciwon daji. 2019; 18 (2): 301-311. doi: 10.1158/1535-7163.MCT-18-0464.
  2. Guada M, Ganugula R, Vadhanam M, Ravi Kumar MNV. Urolithin A yana Rage Ciwon Nephrotoxicity na Cisplatin ta hanyar hana kumburin koda da Apoptosis a cikin Tsarin Gwajin Gwaji. J Pharmacol Exp Ther. 2017; 363 (1): 58-65. doi: 10.1124/jpet.117.242420.
  3. Juan Carlos Espín, Mar Larrosa, María Teresa García-Conesa, Francisco Tomás-Barberán, "Muhimmancin Halittu na Urolithins, Gut Microbial Ellagic Acid-Derived Metabolites: Hujja Ta Farko", Hujja-tushen Hadin gwiwa da Madadin Magunguna, vol. 2013, Labarin ID 270418, shafuka 15, 2013. https://doi.org/10.1155/2013/270418.
  4. Lee G, Park JS, Lee EJ, Ahn JH, Kim HS. Anti-inflammatory da hanyoyin antioxidant na urolithin B a cikin microglia da aka kunna. Phytomedicine. 2019; 55: 50-57. Doi: 10.1016/j.phymed.2018.06.032.
  5. Han QA, Yan C, Wang L, Li G, Xu Y, Xia X. Urolithin A attenuates ox-LDL-induced endothelial dysfunction part by modulating microRNA-27 da ERK/PPAR-γ hanyar. Mol Nutr Abincin Res. 2016; 60 (9): 1933-1943. Doi: 10.1002/mnfr.201500827.