Urolithin A foda

Urolithin A foda Bayani dalla-dalla

name:	Urolithin A.
Chemical Name:	3,8-Dihydroxybenzo [c] chromen-6-one
CAS:	1143-70-0
Tsarin Kiba:	C13H8O4
Girman kwayoyin halitta:	228.2
Color:	Fari zuwa farar fata-fata mai tsabta
Makullin InChi:	RIUPLDUFZCXCHM-UHFFFAOYSA-N
Lambar ta SMILES:	O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3
aiki:	Urolithin A, gut-microbial metabolite na ellagic acid, yana fitar da maganin kumburi, antiproliferative, da kaddarorin antioxidant. Urolithin A yana haifar da nakasa da apoptosis, yana hana ci gaban zagayowar sel, kuma yana hana kwayar halittar DNA.
Application:	Urolithin A metabolite na ellagitannin; Matsakaitan Magunguna
Solubility:	Matsala a cikin DMSO (3 mg / mL).
Ajiye Temp:	Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).
Yanayin Jira:	An shigo da su a ƙarƙashin zazzabi mai zafi azaman ƙwayoyin ƙwayoyi marasa haɗari. Wannan samfurin yana da ƙidayar isa ga 'yan makonni a yayin aikawa na kyauta da lokacin da aka kashe a Kwastam.

 

Urolithin A. Bayanin NMR

Idan kuna buƙatar COA, MSDS, HNMR don kowane samfurin samfur da sauran bayanai, da fatan za a tuntuɓi mu manajan talla.

 

Gabatarwa zuwa Urolithins

Urolithins su ne na biyu na metabolites na ellagic acid da aka samo daga ellagitannins. A cikin mutane ellagitannins suna canzawa ta hanji microflora zuwa ellagic acid wanda ke kara canzawa zuwa urolithins A, urolithin B, urolithin C da urolithin D a cikin manyan hanji.

Urolithin A (UA) shine mafi yawan yaduwar abubuwa na ellagitannins. Koyaya, urolithin A ba a san shi da faruwa ta ɗabi'a a kowace tushen abinci ba.

Urolithin B (UB) yana da wadataccen kwayar halitta wanda aka samar a cikin hanji ta hanyar canji na ellagitannins. Urolithin B shine samfurin ƙarshe bayan duk sauran urolithin sun samo asali. Ana samun Urolithin B a cikin fitsari a matsayin urolithin B glucuronide.

Urolithin A 8-Methyl Ether shine matsakaiciyar samfur yayin kiran Urolithin A. Yana da mahimmancin ci gaba na biyu na ellagitannin kuma yana da abubuwan antioxidant da anti-inflammatory.

 

Tsarin aikin urolithin A da B

Rol Urolithin A yana haifar da mitophagy

Mitophagy nau'i ne na cin gashin kansa wanda ke taimakawa kawar da lalacewar mitochondrial don ingantaccen aikin su. Autophagy yana nufin babban tsari wanda lalacewar abubuwan cytoplasmic kuma saboda haka ana sake yin amfani dasu yayin da mitophagy shine lalata da kuma sake amfani da mitochondria.

Yayin tsufa raguwa a cikin motsa jiki wani bangare ne da ke haifar da raguwar aikin mitochondrial. Bugu da ari, danniya da karfin jiki na iya haifar da karancin motsa jiki. Urolithin A sun mallaki ikon kawar da lalacewar mitochondria ta hanyar amfani da iska.

Properties Abubuwan antioxidant

Oxidative danniya na faruwa lokacin da akwai rashin daidaituwa tsakanin tsatstsauran ra'ayi kyauta da antioxidant a jiki. Wadannan tsattsauran ra'ayi ba sau da yawa ana danganta su da cututtukan cututtukan cututtukan cututtukan zuciya, cututtukan zuciya da ciwon daji.

Urolithins A da B suna nuna tasirin antioxidant ta hanyar ƙarfin su na rage radicals kuma takamaiman matakan oxygen nau'in oxygen (ROS) kuma suna hana peroxidation lipid a cikin wasu nau'ikan sel.

Bugu da ari, urolithins suna iya hana wasu enzymes masu shayarwa, gami da monoamine oxidase A da tyrosinase.

● Abubuwan kariya ga kumburi

Kumburi tsari ne na halitta wanda jikinmu ke yaƙi da duk wani abu da ya faɗi kamar cututtuka, rauni, da ƙananan ƙwayoyin cuta. Koyaya, ciwon kumburi na yau da kullun na iya zama cutarwa ga jiki saboda wannan yana da alaƙa da cuta daban-daban kamar asma, matsalolin zuciya, da kuma cutar kansa. Konewa na yau da kullun na iya faruwa saboda mummunan kumburi, cututtuka ko ma masu kyauta a jiki.

Urolithins A da B sun nuna kaddarorin anti-kumburi ta hanyar hana sinadarin nitric oxide. Suna hana takamaiman sinadarin nitric oxide synthase (iNOS) takaddama da mRNA wanda ke da alhakin kumburi.

Effects Tasirin anti-microbial

Beswayoyin cuta da suka haɗa da ƙwayoyin cuta, fungi da ƙwayoyin cuta suna faruwa ta halitta a cikin yanayi har ma a jikin mutum. Koyaya, microan ƙananan ƙwayoyin cuta da ake magana da su a matsayin ƙwayoyin cuta na iya haifar da cututtukan cututtuka kamar mura, kyanda da malaria.

Urolithin A da B sun iya yin aikin antimicrobial ta hanyar hana ƙwayar kokwamba. Kirkiro ƙwayoyin cuta shine yanayin sadarwa na ƙwayoyin cuta wanda ke sa ƙwayoyin ƙwayoyin cuta don ganowa da sarrafa abubuwan da suka shafi kamuwa da cuta kamar virulence da motility.

Hib Hana glycation mai gina jiki

Glycation yana nufin haɗuwa marar haɗari na enzymatic na sukari zuwa lipid ko furotin. Babban jigon kayan tarihi ne a cikin masu cutar sukari da sauran rikice-rikice har da tsufa.

Babban ƙwayar glycation shine tasirin sakandare na hyperglycemia yana da babban matsayi a cikin rikice-rikicen cututtukan zuciya kamar su ciwon sukari da cutar Alzheimer.

Urolithin A da B sun mallaki kaddarorin anti-glycative wadanda suke dogaro da kansu wadanda basu da izinin aikin antioxidant.

 

Urolithin Amfanin

(1) Iya kara tsawon rai
Urolithin A yana haifar da mitophagy ta hanyar zaɓar da mitochondria lalacewa. Hakanan yana tabbatar da sake yin amfani da mitochondria don ingantaccen aiki. Mitochondria sau da yawa yakan lalace tare da tsufa kuma kuma saboda damuwa. Rashin lalacewa daga mitochondria ya lalace yana taka rawa a tsawan rayuwar.

A cikin nazarin tsutsotsi, urolithin supplementarin da ake gudanarwa a 50 µM daga matakin kwai har zuwa mutuwa an sami haɓaka rayuwar su da 45.4%.

A wani binciken da aka gudanar a cikin 2019 ta amfani da fibroblasts na ɗan adam, urolithin A ƙarin an samo shi don nuna yiwuwar tsufa. Ya sami damar haɓaka bayyanar nau'in 1 na collagen kuma ya rage bayanin matrix metalloproteinase 1.

Karamin binciken ɗan adam ya kuma nuna cewa UA ta sami damar inganta aikin mitochondrial da lafiyar kasusuwa a cikin tsofaffi lokacin da aka gudanar da magana a baki a 500-1000mg har tsawon makonni huɗu.

(2) Taimakawa wajen hana kamuwa da cutar sankara
Urolithins da abubuwan da suka sa gaba, ellagitannins, suna da kaddarorin anti-cancer. Suna da damar hana yaduwar ƙwayar kansa ta hanyar kame-kamewar sel da gabatar da apoptosis. Apoptosis yana nufin mutuwawar kwayar halitta wanda jikin mutum zai kawar da yiwuwar ƙwayoyin kansa-da sauran ƙwayoyin cuta masu kamuwa da cuta.

A cikin nazarin mice allura tare da ƙwayoyin kansa na mutum, an gano ellagitannins metabolites (Urolithin A) don hana ci gaban cutar kansa ta hanji. Binciken ya kara bayar da rahoton mafi girma da yawa daga cikin metabolites a cikin hanjin hanji, hanji da kasusuwa na hanji.

(3) Inganta fahimi
Urolithin A zai iya kare jijiyoyi daga mutuwa kuma yana iya haifar da neurogenesis ta siginar anti-mai kumburi.

A cikin nazarin mice tare da raunin ƙwaƙwalwar ƙwaƙwalwa, an gano urolithin A don rage ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa da kare ƙwayoyin cuta daga apoptosis. Wannan yana ba da shawarar cewa ana iya amfani da UA don magance cutar ta Alzheimer (AD).

(4) Karfin kiba
Bincike ya nuna cewa ellagitannins suna da ikon hana tarawar lipid kuma alamomi na adipogenic kamar su protein na farkon girma na 2 da kuma kayan gina jiki masu iya ingantawa ta hanyar kamawa da zagayowar sel.

Urolithin A an samo shi musamman don inganta haɓakar insulin don haka yana hana haɓakar kiba.

A cikin nazarin mice tare da kiba mai yawa, urolithin An samo ƙari don hana kiba mai yawa cikin abinci da kuma raunin metabolism a cikin mice. Binciken ya nuna cewa maganin UA ya kara kashe kuzarin kuzari saboda haka karamin jiki yake.

 

Urolithin A da kayan abinci na B

Urolithins ba a san ana iya samo shi ta halitta a kowane tushen abinci ba. Su samfuri ne na canji na ellagic acid wanda aka samo daga ellagitannins. Ellagitannins an canza shi zuwa acid ellagic ta gut microbiota kuma ana kara inganta ellagic acid a cikin metabolites din (urolithins) a cikin manyan hanji.

Ellagitannins na faruwa ne ta hanyar abinci kamar su rumman, 'ya'yan itace ciki har da strawberries, raspberries, girgije da baƙi, muscadine inabi, almond, guavas, shayi, da kwayoyi kamar gyada da kirji da giya mai tsufa misali ruwan inabi da wuski daga ganyen itacen oak.

Don haka zamu iya kammala abinci da abinci na urolithin B sune abinci mai wadataccen ellagitannin. Ya kamata a lura cewa ellagitannin bioavailability yana da iyakantacce yayin da kwayarsa ta biyu (urolithins) ke samuwa a sauƙaƙe.

Urolithins fitarwa da samarwa sun bambanta tsakanin mutane tunda tuba daga ellagitannins sun dogara da microbiota a cikin hanji. Akwai takamaiman kwayoyin cuta da ke cikin wannan jujjuyawar kuma sun bambanta tsakanin mutane inda wasu ke da babban, ƙarancin ko babu wadataccen microbiota. Hakanan hanyoyin abinci sun bambanta a matakan ellagitannins. Saboda haka fa'idodi masu amfani na ellagitannins sun bambanta daga mutum ɗaya zuwa wancan.

 

Rolarin Urolithin A da B

Rolarin Urolithin A da na Urolithin B ana samun su a kasuwa a matsayin kayan abinci mai wadataccen ellagitannin. Urolithin Ana samun wadatar kari. Mafi yawan abubuwan rumman an sayar dasu sosai kuma anyi amfani dasu tare da nasara. Ana hada wadannan kari daga 'ya'yan itacen ko kwaya kuma an tsara su cikin ruwa ko hoda.

Saboda bambance-bambancen da ke cikin tattarawar ellagitannins a cikin abinci daban-daban, abokan cinikin urolithin sun saya shi suna la'akari da tushen abinci. Hakanan ya shafi lokacin samowa don urolithin B foda ko kari na ruwa.

Fewan binciken karatun ɗan adam da aka gudanar tare da urolithin A foda ko B ba su bayar da rahoton wani mummunan sakamako mai illa daga gudanar da waɗannan abubuwan ƙarin ba.

reference

1. Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Ƙaddarar Metabolic na Ellagitannins: Tasirin Lafiya, da Ra'ayoyin Bincike don Abincin Aiki Mai Aiki". Bayani mai mahimmanci a Kimiyyar Abinci da Gina Jiki.
2. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Nuwamba 2009). "Urolithins, metabolites microbial metabolites na Pomegranate ellagitannins, suna nuna aikin antioxidant mai ƙarfi a cikin gwajin tushen sel". J Agric Abincin Chem.
3. Bodwell, Graham; Pottie, Ian; Nandaluru, Penchal (2011). "Ƙaƙƙarfan Wutar Lantarki-Buƙatar Diels-Alder-based Total Synthesis of Urolithin M7".