Spermidine

Bayanan Bayani na Spermidine

Menene Spermidine (124-20-9)?

Spermidine polyamine ne, ma'ana yana da rukunin amino guda biyu ko fiye. Yana faruwa ne a zahiri kuma ana haɗuwa da shi sosai a cikin ribosomes da kyallen takarda masu rai. Yana yana taka muhimmiyar rawa a cikin aikin tantanin halitta da rayuwa.

Spermidine na iya hana fibrosis na hanta da ciwon hanta wanda ke daya daga cikin abubuwan da ke haifar da ciwon hanta. Ana amfani da shi a cikin kari wanda, lokacin da aka sha, akai-akai, zai iya yin tasiri mai mahimmanci akan tsawon rai.

Spermidine da putrescine an san su don tayar da autophagy. Tsarin da ke wargaza sharar gida a cikin sel da sake yin amfani da sassan salula. Yana da mahimmancin tsarin kula da inganci ga mitochondria, matattarar ƙarfin sel. Autophagy yana ba da damar lalata mitochondria mai lahani da lalacewa da zubar da shi. Zubar da mitochondria yana da ƙarfi sosai fiye da yadda aka yi imani da shi.

Polyamines na iya ɗaure ga nau'ikan kwayoyin halitta daban-daban da ke sa su da amfani sosai. Suna tallafawa matakai, gami da haɓakar tantanin halitta, kwanciyar hankali na DNA, haɓakar tantanin halitta, da apoptosis. Har ila yau, ya bayyana cewa polyamines suna aiki a irin wannan hanya zuwa abubuwan haɓakawa yayin rarraba tantanin halitta. Wannan shine dalilin da ya sa putrescine da spermidine suna da mahimmanci don haɓakar ƙwayar nama da aiki.

Spermidine (124-20-9) amfanin

Spermidine anti-mai kumburi Properties

An yarda da cewa yayin da kumburi ke taka rawar gani wajen warkar da raunuka da kuma tunkuɗe masu kamuwa da cuta, kumburin da ke da alaƙa da tsufa, wanda galibi ake kira kumburi, yana da illa. Kumburi na yau da kullun yana hana farfadowar nama mai lafiya, yana haifar da ƙwayoyin rigakafi su zama marasa aiki, har ma yana iya haɓaka saurin da ƙwayoyin lafiya suka zama hankalta. Spermidine yana bayyana yana rage wannan kumburi na yau da kullun kuma yana iya ragewa hanya ɗaya da sel da kyallen takarda ke tsufa.

Spermidine kuma yana iya jinkirta tsufa

A kan tsayin daka, an nuna kulawar spermidine don ƙara yawan rayuwa a yawancin nazarin dabbobi kuma yana hana hanta fibrosis da ciwon daji na hepatocellular. Wannan kuma yana bayyana yanayin yanayin abinci mai wadatar polyamines [13]. Har ila yau, akwai wasu shaidun da ke nuna cewa yana inganta juriya ga danniya da kuma cewa raguwar shekarun haihuwa na spermidine yana goyan bayan farkon cututtukan da suka shafi shekaru.

Lipid metabolism sananne ne mai tsara tsawon rayuwa, kuma rashin aiki na lipid metabolism na iya samun babban tasiri ga tsawon lafiya da tsawon rayuwa. Matsayin da spermidine ke takawa a cikin tsarin adipogenesis, ƙirƙirar adipocytes (masu kitse) daga sel mai tushe, da ikonsa na canza bayanan martaba na iya ba da shawarar wata hanyar da spermidine ke tasiri tsawon rayuwa. Spermidine yana sauƙaƙe bambance-bambancen ƙwayoyin preadipocyte a cikin ƙwayoyin adipocyte balagagge a matsayin wani ɓangare na tsarin adipogenesis.

Idan an haɗa waɗannan mahadi tare, haɗuwa da ingantaccen autophagy, rage ƙumburi, ƙananan matakan damuwa na oxidative a cikin tantanin halitta, inganta haɓakar ƙwayar ƙwayar cuta, da ingantaccen ƙwayar lipid na iya taimakawa wajen inganta lafiyar lafiya.

Spermidine na iya rage raguwar fahimi

Bincike da aka buga a cikin 2021 a cikin mujallar Cell Reports yana ba da cikakken bayani game da haɓaka spermidine na abinci cognition da aikin mitochondrial a cikin kudaje da beraye, tare da wasu bayanan ɗan adam masu yiwuwa don kashe shi. Duk da yake wannan binciken ya kasance mai ban sha'awa, yana da wasu iyakoki, kuma ƙarin bayanan amsa kashi shine da ake buƙata kafin a iya yanke hukunci game da fa'idodi ga fahimtar mutum.

Spermidine (124-20-9) Aikace-aikace?

Spermidine don ciwon daji da lafiyar zuciya

Akwai kuma wasu shaidun da ke nuna zai iya rage haɗarin cututtukan zuciya. A cikin binciken 2016, an gano spermidine don mayar da agogon tsufa da inganta aikin zuciya na zuciya a cikin tsofaffin beraye. A matakin gabobin jiki, tsarin zuciya da aiki sun inganta a cikin tsofaffin berayen da aka ba da spermidine. Haka kuma berayen sun ga ingantuwa ga metabolism na su saboda maido da tsarin mitochondrial da aikin bin kari na spermidine.

A cikin mutane akwai binciken da ya danganci yawan jama'a guda biyu (wanda aka taƙaita a cikin takarda ɗaya) waɗanda bayanan da ke nuna cewa shan spermidine yana da alaƙa da raguwar duk abin da ya haifar, cututtukan zuciya da jijiyoyin jini da ciwon daji a cikin mutane.

Bisa ga wannan bayanai da sauran binciken, wasu masu bincike sun kammala cewa spermidine yana jinkirta tsufa a cikin mutane. Ya kamata mu yi taka tsantsan a wannan matakin domin har yanzu kwanakin farko ne na spermidine amma bayanan ya zuwa yanzu ya cancanci ƙarin bincike don ganin ko za a iya tabbatar da wannan tasirin rigakafin tsufa.

Nazarin lura da ɗan adam kuma ya sami alaƙa tsakanin shan spermidine na abinci tare da rage haɗarin ciwon daji na hanji.

Wadanne abinci ne suke da yawan sinadarin spermidine?

Akwai tushen abinci da yawa na maniyyi ciki har da innabi, kayan waken soya, legumes, masara, dukan hatsi, chickpeas, Peas, barkono kore, broccoli, lemu, koren shayi, shinkafa shinkafa, da barkono barkono.

Hakanan ana iya samun shi a cikin namomin kaza na shitake, hatsin amaranth, ƙwayar alkama, farin kabeji, broccoli, da nau'ikan cuku waɗanda balagagge, da durian.

Ya kamata a lura da cewa yawancin abincin da ke cikin Rumunan ya ƙunshi abinci mai arziki na spermidine. Wannan na iya aƙalla bayyana abubuwan mamaki na "yankunan shuɗi" da kuma dalilin da yasa mutane a can sukan rayu tsawon lokaci fiye da sauran wurare.

Idan kuna gwagwarmaya don samun isasshen abinci a cikin abincin ku kuma kuna iya samun shi azaman kari na spermidine. Maniyyi na roba da ake amfani da shi a cikin kari yayi daidai da kwayoyin halitta da ke faruwa.

Spermidine foda na siyarwa (Inda za a saya Spermidine foda a girma)

Kamfaninmu yana jin daɗin dogon lokaci tare da abokan cinikinmu saboda muna mai da hankali kan abokin ciniki sabis da samar da manyan samfurori. Idan kuna sha'awar samfuranmu, muna da sassauƙa tare da tsara umarni don dacewa da takamaiman buƙatarku kuma lokacin saurin jagorancinmu akan umarni yana bada tabbacin za ku ɗanɗana samfurinmu akan lokaci. Har ila yau, muna mai da hankali kan ƙarin sabis ɗin ƙimar. Muna nan don tambayoyin sabis da bayani don tallafawa kasuwancin ku.

Mu masu sana'a ne Spermidine foda maroki na shekaru da yawa, muna ba da samfura tare da farashi mai gasa, kuma samfurinmu yana da mafi girman inganci kuma yana fuskantar tsauraran gwaji mai zaman kansa don tabbatar da cewa yana da aminci don amfani a duk duniya.

References

1. R. de Cabo, D. Carmona-Gutierrez, M. Bernier, MN Hall, F. Madeo, Neman rigakafin tsufa: Daga elixirs zuwa tsarin azumi. Cell 157, 1515-1526 (2014). 10.1016/j.cell.2014.05.031
2. C. López-Otín, L. Galluzzi, JMP Freije, F. Madeo, G. Kroemer, Metabolic iko na tsawon rai. Cell 166, 802-821 (2016). 10.1016/j.cell.2016.07.031
3. L. Fontana, L. Partridge, VD Longo, Tsawaita tsawon rayuwar lafiya-Daga yisti ga mutane. Kimiyya 328, 321-326 (2010). 10.1126/kimiyya.1172539
4. VD Longo, S. Panda, Azumi, Circadian rhythms, da ƙuntataccen ciyarwa a cikin tsawon rayuwa mai lafiya. Cell Metab. 23, 1048-1059 (2016). 10.1016/j.cmet.2016.06.001

Samu farashi mai yawa