Mafi kyawun Pyridoxal hydrochloride foda Manufacturer

Pyridoxal hydrochloride (65-22-5) Gurasar ruwa mai laushi

Bari 11, 2021

Cofttek shine mafi kyawun masana'antar foda Pyridoxal hydrochloride a China. Masana'antarmu tana da cikakken tsarin sarrafa sarrafawa (ISO9001 & ISO14001), tare da damar samarwa na kowane wata na 320kg.

 


Status: A Mass Production
Naúra: 1kg / jaka, 25kg / Drum

Pyridoxal hydrochloride (65-22-5) Gurasar ruwa mai laushi Sfasali

name: Pyridoxal hydrochloride
CAS: 65-22-5
tsarki 98%
Formula kwayoyin: C8H10ClNO3
Kwayoyin Weight: 203.622 g / mol
Shawarwar Melt: 173 ° C
Chemical name: PYRIDOXAL HYDROCLORIDE

Pyridoxal HCl 3-Hydroxy-5- (hydroxymethyl) -2-methylisonicotinaldehyde hydrochloride

Kamancin: 3-hydroxy-5- (hydroxymethyl) -2-methyl-4-pyridinecarboxaldehyde hydrochloride / Pyridoxal HCl
InChI Key: FCHXJFJNDJXENQ-UHFFFAOYSA-N
Rabin Rayuwa: N / A
Solubility: Narkewa cikin ruwa
Yanayin Adana: 0 - 4 C don gajere (kwanaki zuwa makonni), ko -20 C na dogon lokaci (watanni)
Application: Ana buƙatar kula da lafiyar jijiyoyi, fata, da sel jini. An yi amfani da Pyridoxine don hana ko bi da wani cuta na jijiya (na gefe neuropathy) wanda wasu magunguna suka haifar (kamar isoniazid).
Appearance: Farin farin-foda

 

Pyridoxal hydrochloride (65-22-5) Gurasar ruwa mai laushi Bayanin NMR

Pyridoxal hydrochloride (65-22-5) Gurasar ruwa mai laushi

Idan kuna buƙatar COA, MSDS, HNMR don kowane samfurin samfur da sauran bayanai, da fatan za a tuntuɓi mu manajan talla.

 

Menene Pyridoxal Hydrochloride?

Pyridoxal hydrochloride wani nau'in bitamin B6 ne. A matsayin nau'in 4-carbaldehyde na bitamin B6, ana yin shi ta hanyar haɗa pyridoxal tare da molar kwatankwacin acid hydrochloric. Yana da kari mai gina jiki. Tsarin sunadarai shine C8H10ClNO3. Sunan IUPAC shine 3-hydroxy-5- (hydroxymethyl) -2-methyl pyridine-4-carbaldehyde hydrochloride.

Wannan kayan yana cikin rukunin mahaɗan mahaɗan da ake kira pyridoxal da abubuwan da suka samo asali. Waɗannan suna ƙunshe da rabe -raben pyridoxal tare da zobe na pyridine wanda ke da sauyawa a wurare daban -daban. Waɗannan wuraren maye sun haɗa da ƙungiyar methyl a matsayi na 2, ƙungiyar hydroxyl a matsayi na 3, ƙungiyar carbaldehyde a matsayi na 4, da ƙungiyar hydroxymethyl a matsayi na 5.

Ana amfani da Pyridoxal hydrochloride a cikin maganin nephropathy mai ciwon sukari. Ana buƙata don kula da lafiyar jijiyoyi, fata, da sel jini. Jiki yana amfani da shi don yin neurotransmitters kamar serotonin da norepinephrine. Hakanan yana taimakawa yin sphingolipids da aminolevulinic acid. Pyridoxal hydrochloride yana canzawa zuwa pyridoxal 5-phosphate, coenzyme don hada amino acid.

Tun da ba za a iya samar da bitamin B6 ta jiki ba yana buƙatar cinye shi daga wurare daban -daban ko ta hanyar kari. Ya wanzu ta hanyoyi da yawa daya daga cikinsu shine pyridoxal wanda shine nau'in 4-carboxaldehyde na bitamin B6 da kuma cofactor don yawancin ayyukan rayuwa.

Pyridoxal hydrochloride shine nau'in gishiri na pyridoxal kuma yana canzawa cikin sauƙi a cikin pyridoxal phosphate wanda kuma aka sani da PLP bayan gudanarwa kuma yana aiki azaman coenzyme don ayyukan rayuwa.

 

Ta yaya Pyridoxal Hydrochloride ke Aiki?

Vitamin B6 yana da sifofi guda uku a yanayi: pyridoxine, pyridoxal, da pyridoxamine, dukkansu suna jujjuya su cikin sifar su a cikin jiki kuma ana kiran su pyridoxal 5'-phosphate. Alamun rashin bitamin B6 sune seborrheic dermatitis, microcytic anemia, glossitis, convulsions, peripheral neuropathy, depression, da dai sauransu. don cika bitamin B6 a cikin jiki.

Pyridoxal hydrochloride shine farkon pyridoxal 5'- phosphate. Bayan cinye pyridoxal hydrochloride, ana canza shi zuwa pyridoxal 5-phosphate a cikin hepatocytes da ƙwayoyin mucosal na hanji. Daga nan sai jini ya ɗauke shi ya rarraba cikin jiki duka. Yana da hannu a yawancin nau'ikan halayen metabolism. Wannan ya haɗa da samuwar da haɓaka amino acid da glycogen. Hakanan yana iya taimakawa haɓaka ƙwayoyin acid, haemoglobin, da neurotransmitters.

Pyridoxal 5'-phosphate coenzyme ne wanda ke cikin metabolism amino acid. Yana aiki azaman coenzyme a cikin duk halayen transamination. Hakanan yana da hannu a cikin oxidation da lalata lalata amino acid.

Ƙungiyar aldehyde da ke cikin pyridoxal 5'-phosphate ta samar da haɗin gwiwar Schiff-base tare da ƙungiyar epsilon-amino na takamaiman ƙungiyar lysine na enzymes aminotransferase. Ƙungiyar alpha-amino na substrate amino acid sannan ta kawar da ƙungiyar epsilon-amino. Wannan yana haifar da samuwar adimine, wanda ke lalacewa. Bayan wannan, ya zama tsaka -tsakin quinoid wanda ke karɓar protons a wurare daban -daban kuma a ƙarshe ya zama ketimine. Sannan Ketimine yana samun isasshen ruwa don ƙungiyar amino ta ci gaba da kasancewa a cikin hadaddun sunadaran.

Pyridoxal hydrochloride kuma yana taimakawa haɓaka ƙwayoyin neurotransmitters kamar serotonin, dopamine, norepinephrine, da gamma-aminobutyric acid.

FDA ba ta amince da Pyridoxal hydrochloride don amfani da FDA ba tukuna.

 

kira

Pyridoxal hydrochloride an haɗa shi daga halayen kwayoyin ta hanyar amsa pyridoxamine tare da molar acid na hydrochloric. Hakanan ana iya haɗa Pyridoxal hydrochloride ta zaɓin oxyidation. Amsar ta ƙunshi ɗaukar pyridoxine hydrochloride azaman kayan farawa kuma za a aiwatar da hanyar oxyidation na catalytic a cikin ruwa. Oxidation na catalytic ya haɗa da tushen iskar oxygen, mai haɓakawa, gishirin inorganic, da amine ligand. Ƙarshen samfur na oxyidation na catalytic zai zama pyridoxal hydrochloride.

 

Pharmacokinetics na Pyridoxal Hydrochloride

Dakatarwa: Ana samun sauƙin shafar su ta hanyar watsawa ta yau da kullun kuma shayarwar su galibi ana samun su a cikin ƙwayoyin mucosal na hanji waɗanda ke da wadata a pyridoxine kinase da pyridoxal phosphate.

 

Metabolism: Yawancin waɗannan mahaɗan kwayoyin halittar da hanta ke ɗaukar su kuma sakamakon abin da ake samu ana yin shi ta hanyar watsawa mai ɗaukar hoto da tarko na rayuwa kamar mahaɗan phosphate. Phosphorylation na mahadi yana faruwa cikin hanta.

 

rarraba: Free pyridoxal phosphate a cikin hanta yana hydrolyzed zuwa pyridoxal, wanda daga baya aka fitar dashi kuma ya ɗaure zuwa haemoglobin da albumin a cikin erythrocytes. Sashin dephosphorylated yana barin tantanin halitta ta hanyar yaduwa kuma saboda haka ba za a sami tarin pyridoxal phosphate a cikin kyallen takarda ba.

 

Fitarwa: Pyridoxal kyauta wanda ya rage a cikin hanta yana cikin sauri zuwa oxidized zuwa 4-pyridoxic acid kuma shine babban kayan fitar da fili. Oxidation zuwa 4-pyridoxic acid yana shiga tsakani ta hanyar aldehyde dehydrogenase, wanda ke yaduwa a cikin kyallen takarda masu yawa, ana kuma yin oxyidation ta hanyar enzymes na hanta da hanta aldehyde oxidase. Babban hanyar fitowar pyridoxal hydrochloride bayan metabolism shine ta fitsari.

 

Fa'idodin Pyridoxal Hydrochloride

Akwai amfani da yawa don pyridoxal hydrochloride. Koyaya, yawancin waɗannan amfani har yanzu ana kan bincike kuma ba za a iya la'akari da takamaiman amfanin wannan fili ba.

Anan akwai wasu fa'idodin pyridoxal hydrochloride

 

Tasiri akan Ciwon Ciwon Ciwon Ciki

Sakamakon Pyridoxal hydrochloride samfurin pyridoxal 5'-phosphate na iya hana samuwar samfuran ƙarshen glycation (AGEs). Yana yin wannan ta tarkon 3-deoxyglucosone. A cikin binciken tare da berayen masu ciwon sukari da ke haifar da streptozotocin, an bi da su tare da pyridoxal 5-phosphate na makonni 16 [1]. Sakamakon ya nuna raguwa mai yawa a cikin albuminuria, hauhawar jini na duniya, fadada mesangial, da fibrosis interstitial. Hakanan ya rage matakan AGEs. Don haka, a cikin dogon lokaci, pyridoxal hydrochloride na iya rage nephropathy da ke faruwa a cikin ciwon sukari.

 

Tasiri a matsayin Metabolite

Pyridoxal hydrochloride da pyrimidine 5'-phosphate suna aiki azaman mahimman abubuwan da ake buƙata yayin halayen rayuwa. Ikon su na yin aiki azaman coenzyme yana buƙatar duka jikin ɗan adam har ma da abubuwa daban -daban da ƙwayoyin cuta kamar Escherichia coli, Saccharomyces cerevisiae, mice. Suna da mahimmanci don samar da mahadi daban -daban da ake buƙata a cikin jiki.

 

Tasiri akan Neurotransmitters

Pyridoxal hydrochloride na iya taimakawa wajen samar da masu watsawa daban -daban a cikin jiki.

 

Tasirin Anemia

A wasu karancin jini, bitamin B6 ya zama dole don samarwa azaman kari. Pyridoxal hydrochloride na iya taimakawa samar da mahimmancin pyridoxal 5'-phosphate don magance irin wannan yanayin.

 

Amfani a Binciken Likitoci

Pyridoxal 5'-phosphate, abin da ke haifar da pyridoxal hydrochloride, ya zama dole ga wasu ƙwayoyin cuta masu dacewa da lafiya. Yana da don tabbatar da ci gaban su daidai. Ya ƙunshi ƙwayoyin cuta irin su Granulicatella da Abiotrophia [2]. Bukatar abinci mai gina jiki na pyridoxal hydrochloride na iya haifar da al'adun ci gaban tauraron dan adam a cikin waɗannan ƙwayoyin cuta. A cikin al'adar in vitro, waɗannan ƙwayoyin cuta na iya girma ne kawai a wuraren da akwai wasu ƙwayoyin cuta na pyridoxal. Ofaya daga cikin manyan mahimman bayanai game da mahallin pyridoxal shine cewa maiyuwa ya samo asali azaman tsoffin maganin gurɓataccen iska a duniya.

 

Hanyoyin Gefen Pyridoxal Hydrochloride

  • Skin irritation
  • Hypersensitivity
  • Haushi na numfashi
  • Tashin zuciya
  • Vomiting
  • Tsinkaya neuropathy
  • Rage jin daɗi
  • ciwon kai
  • Lambobi
  • Tingling
  • Dama tada

 

Hulɗa na Pyridoxal Hydrochloride Tare da Wasu Magunguna

Babu isasshen bayani game da hulɗar kai tsaye ta pyridoxal hydrochloride tare da wasu magunguna. Koyaya, akwai bayanin da aka sani game da ma'amala ta haɗin pyridoxal 5'-phosphate tare da wasu magunguna.

Wasu daga cikin waɗannan mu'amalolin sune:

Amiodarone -A kan hulɗa tare da pyridoxine 5'-phosphate, yana iya ƙara yawan hankali ga haske, haifar da kunar rana a jiki, da sauransu.

Phenytoin -Pyridoxine 5'-phosphate na iya haɓaka metabolism na phenytoin a cikin jiki, yana haifar da ƙarancin tasirin ƙarshen.

Phenobarbital -Pyridoxine 5'-phosphate na iya haɓaka lokacin rushewar phenobarbital.

Levodopa - Yana iya haifar da saurin metabolism na levodopa.

Yayin da aka san raunin pyridoxine yana faruwa a cikin ciki da shayarwa, babu wani bayani game da tasirin pyridoxal hydrochloride a cikin waɗannan yanayin. Saboda haka, an ba da shawarar yin taka tsantsan.

 

A ina za a sayi Pyridoxal Hydrochloride a cikin 2021?

Kuna iya siyan foda pyridoxal hydrochloride kai tsaye daga kamfanin kera pyridoxal hydrochloride. Akwai shi a cikin adadin 1kg a kowace jakar ko 15kg a kowace ganga. Koyaya, ana iya daidaita wannan gwargwadon bukatun mai amfani. Ana buƙatar adana wannan foda a zafin jiki na 0 zuwa 4 ° na ɗan gajeren lokaci da -20 ° C na dogon lokaci.

Ana samun Pyridoxal hydrochloride foda a cikin foda mai launin fari ko koren launi. Anyi shi da mafi kyawun sinadarai a ƙarƙashin kulawa mai ƙarfi don tabbatar da cewa masu amfani suna samun mafi kyawun samfurin.

 

References

  1. Nakamura, S., Li, H., Adijiang, A., Pischetsrieder, M., & Niwa, T. (2007). Pyridoxal phosphate yana hana ci gaban nephropathy mai ciwon sukari. Nephrology Dialysis Dasawa, 22(8), 2165-2174.
  2. Kitada, K., Okada, Y., Kanamoto, T., & Inoue, M. (2000). Abubuwan Serological na Abiotrophia da nau'in Granulicatella (streptococci mai bambancin abinci). Kwayoyin cuta da kuma ilimin halittar jiki, 44(12), 981-985.