Mafi kyawun J-147 (1146963-51-0) Maƙerin foda - Cofttek

J-147 (1146963-51-0)

Bari 7, 2021

Cofttek shine mafi kyawun masana'antar foda J-147 a China. Masana'antarmu tana da cikakken tsarin sarrafa samarwa (ISO9001 & ISO14001), tare da damar samarwa kowane wata na 120kg.

 


Status: A Mass Production
Naúra: 1kg / jaka, 25kg / Drum

J-147 (1146963-51-0) Sfasali

name: J-147
CAS: 1146963-51-0
tsarki 98%
Formula kwayoyin: C18H17F3N2O2
Kwayoyin Weight: 350.341 g / mol
Shawarwar Melt: 177-178 ° C
Chemical name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Kamancin: N- (2,4-Dimethylphenyl) -2,2,2-trifluoro-N '- [(E) - (3-methoxyphenyl) methylene] acetohydrazide
InChI Key: HYMZAYGFKNNHDN-SSDVNMTOSA-N
Rabin Rayuwa: 1.5 awo a cikin plasma da 2.5 hours a cikin kwakwalwa
Solubility: Matsaloli zuwa 100 mil a cikin DMSO kuma zuwa 100 mil a cikin ethano
Yanayin Adana: 0 - 4 C don gajere (kwanaki zuwa makonni), ko -20 C na dogon lokaci (watanni)
Application: J-147 foda sabon magani ne na gwaji wanda ake kirkiro shi azaman magani na cutar Alzheimer.
Appearance: Farin farin-foda

 

J-147 (1146963-51-0) Bayanin NMR

J-147 (1146963-51-0)

Idan kuna buƙatar COA, MSDS, HNMR don kowane samfurin samfur da sauran bayanai, da fatan za a tuntuɓi mu manajan talla.

 

Menene J-147 (1146963-51-0)?

J-147 foda shine sabon magani na gwaji wanda ake haɓaka azaman magani mai yiwuwa don cutar ta Alzheimer. Zuwa yanzu, gwaje-gwajen da aka yi akan bera suna nuna alkawura da yawa. J147 ya ba da rahoton sakamako a cikin sake juyo tasirin cutar dementia da Alzheimer a cikin nau'ikan linzamin kwamfuta. J147 yana ɗaukar wata hanya dabam idan aka kwatanta da sauran magungunan Nootropics da Alzheimer. J147 yayi kokarin cire kwandon shara a cikin kwakwalwa. Masu binciken sun kuma lura cewa J147 na da damar magance wasu maganganun tsufa na ilimin halittu, ba kawai asarar ƙwaƙwalwa ba. Magungunan na iya taimakawa wajen hana zub da jini daga microvessels, kamar yadda aka nuna ta hanyar gwajin mice da aka yi har yanzu. An fara samar da magungunan ne a cikin 2011. Tun daga wannan lokacin, anyi gwaje-gwaje a kan mice amma ba mu ga wani gwaji na gwajin da ya shafi mutum ba. Koyaya, wasu bincike da aka buga a bara sun nuna kyakkyawan hoto game da yadda J147 yake aiki a cikin kwakwalwar ɗan adam. A cewar takarda, maganin yana ɗaure zuwa furotin mitochondria. Kwayoyin Mitochondria galibi suna da alhakin samar da makamashi. Ayyukan J147 a kansu yana haɓaka sakewar sel. Wannan farfadowa yana da mahimmanci wajen juyar da ƙwaƙwalwar ƙwaƙwalwar ajiya da haɓaka lafiyar ƙwaƙwalwar gaba ɗaya.

 

J-147 (1146963-51-0) fa'idodi

Wataƙila Rashin Tsarin Digirin Digiri

J147 ya nuna alkawura da yawa a cikin jujjuyawar cututtukan ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa kamar Alzheimer da sauran su. A cikin gwaje-gwajen da aka yi a kan nau'ikan linzamin kwamfuta har zuwa yanzu, magungunan sun nuna matukar tasiri ga ma'amala da waɗannan yanayin.

J147 yana aiki ta hanyar taimakawa sel a cikin kwakwalwa su sake haɓakawa, yana sa su ƙarami da aiki fiye da tsofaffin ƙwayoyin. Koyaya, yana da mahimmanci a san cewa babu wani gwaji na ɗan adam da aka yi akan sakamakon J147. Da fatan, hakan zai faru ba da daɗewa ba amma har yanzu ana iya siyar da maganin a matsayin foda a cikin dillalai na kan layi.

 

Inganta Mitochondria Action da Longevity

J147 yana aiki ta hanyar ɗaure cikin mitochondria, ƙwayoyin da ke da alhakin samar da makamashi a jikinmu. Ayyukan J147 yana taimakawa wajen hana damuwa oxidative a cikin ƙwayoyin mitochondria, yana haifar da mafi kyawun aikin sel da tsawon rai.

J147 kuma yana taimakawa rage metabolites mai guba wanda zai iya haifar da wucewar ƙwayar cuta, tsari wanda sel ke mutuwa ta hanyar yin kwalliya sosai. Wannan yana ba da damar ƙwayoyinku su kasance cikin sabo da lafiya tsawon lokaci. A zahiri, wasu hanyoyin da aka yi akan batutuwan dabba sun nuna cewa gudanarwar J147 akan kwariyen 'ya'yan itace sun tsawaita rayuwarsu ta hanyar 9.5 zuwa 12.8%.

 

Inganta ƙwaƙwalwar ajiya

J147 ya kuma nuna alkawura da yawa tsakanin ƙirar motsi na gwaji a haɓaka ƙwaƙwalwa. Magungunan har ila yau sun taimaka wajen juyar da gawuwar ƙwaƙwalwa a cikin mazannin gwaji yayin nazarin binciken.

Masu binciken sun yi imanin cewa ana iya yin amfani da waɗannan tasirin a cikin abubuwan mutum. Hakanan akwai wasu hujjoji da ke ba da shawara cewa za a iya bincika J147 a matsayin magani don yiwuwar ƙwaƙwalwar sarari.

 

Yana Kare Neurons kuma Yana Taimakawa Girmar kwakwalwa

J147 kuma yana da kaddarorin neuroprotective waɗanda ke hana aikin hada ƙarfi abu a cikin sel. Wannan yana taimakawa kare neurons daga lalacewa mai yiwuwa. J147 na iya kasancewa mai haifar da ci gaban kwakwalwa. J147 na iya inganta synaptic plasticity a cikin kwakwalwa, yana haifar da ci gaba.

 

J-147 (1146963-51-0) amfani?

Yana Inganta Haɓakawa

J-147 kari yana haɓaka sararin samaniya da ƙwaƙwalwar ajiya na dogon lokaci. Magungunan miyagun ƙwayoyi suna canza lahani na hankali tsakanin tsofaffi waɗanda ke fama da rashin lahani. J-147 don siyarwa ana samun sa azaman kanshin kanti ne kuma samari suna ɗaukar shi don haɓaka ƙarfin koyo. Shan magungunan J-147 na tsufa zai kuma inganta ƙwaƙwalwar ajiya, hangen nesa, da tsabtar hankali.

 

Gudanar da Cutar Alzheimer

J-147 yana amfanar da marasa lafiya da cutar Alzheimer ta hanyar rage ci gaban yanayin. Misali, shan kari yana rage matakan beta-amyloid (Aβ) mai narkewa, wanda ke haifar da rashin aiki. Bayan haka, J-147 curcumin yana canza siginar neurotrophin don tabbatar da rayuwar neuronal, sabili da haka, ƙirƙirar ƙwaƙwalwar ajiya da cognition.

Marasa lafiya tare da AD suna da ƙananan abubuwan neurotrophic. Koyaya, shan ƙarin J-147 na Alzheimer yana haɓaka duka NGF da BDNF. Waɗannan ƙananan ƙwayoyin cuta suna taimaka wa ƙwaƙwalwar ajiya, koyo, da ayyukan fahimi.

 

J-147 (1146963-51-0) sashi

Karatu daban-daban sunyi amfani da nau'ikan maganin daban akan beraye, amma ɗayan karatun da aka inganta shine ya baiwa beraye 10 mg / kg na nauyin jiki kowace rana. Wani binciken ya yi amfani da magungunan 1, 3 ko 9 mg / kg, kuma ya sami sakamako mai dogaro da kashi, tare da ɗimbin ɗimbin aiki da kyau.

Koyaya, fassara wannan zuwa ƙimar ɗan adam na buƙatar daidaitawa don yanayin farfajiyar jiki. Dangane da tsarin jujjuyawar da aka fi amfani da shi, adadin daidai-daidaiton ɗan adam ya kamata ya daidaita sashin linzamin da aka raba ta 12.3 – ko .81 MG da kilogiram na nauyin jiki kowace rana.

Wannan .36 MG na J147 a kowace laban nauyin jiki kowace rana. Wannan zai zama MG 36 a rana don mutum mai fam ɗari, 54 MG ga mutum fam 150, ko 72 MG ga mutum fam 200.

Koyaya, sauran karatun sun sami sakamako mai kyau daga ƙananan ƙananan ƙwayoyi, kuma an basu cewa J147 yana ƙaddamar da kwakwalwa, ba a bayyane yake ba cewa sashi zaiyi daidai bisa girman jiki.

Kamar wannan, ya kamata a duba waɗannan lambobin azaman iyakokin sama, kuma akwai kowane dalili da za a gaskata cewa 10 zuwa 20 MG a rana ya isa ya sami wani sakamako.

 

J-147 foda for sale(Inda zaka sayi foda J-147 a cikin girma)

Kamfaninmu yana jin daɗin haɗin kai tare da abokan cinikinmu saboda mun mai da hankali kan sabis na abokin ciniki da samar da samfuran manyan kayayyaki. Idan kuna da sha'awar samfurinmu, muna jujjuya tare da ƙirƙirar umarni don dacewa da takamaiman buƙatunku da lokacin jagoranmu na sauri akan umarni wanda zai ba ku tabbacin ku ɗanɗano samfurinmu akan lokaci. Hakanan muna mai da hankali kan ayyukan ƙara ƙimar. Muna samuwa don tambayoyin sabis da bayani don tallafawa kasuwancin ku.

Mu ƙwararren mai samar da hoda ne na J-147 na tsawon shekaru, muna samar da kayayyaki da farashi mai fa'ida, kuma samfuran mu yana da inganci kuma yana fuskantar tsayayye, gwaji mai zaman kansa don tabbatar da cewa amintacce ne don amfani a duk duniya.

 

References

[1] “Gwajin gwajin da aka yi niyyar cutar Alzheimer ya nuna tasirin tsufa” (Sanarwar sanarwa). Cibiyar Salk. 12 Nuwamba 2015. An dawo da Nuwamba 13, 2015.

[2] Brian L. Wang (13 Nuwamba 2015). "Magungunan gwaji da ke niyya akan cutar Alzheimer na nuna tasirin tsufa a gwajin dabbobi". nextbigfuture.com. An sake dawo da Nuwamba 16, 2015.

[3] Solomon B (Oktoba 2008). “Filamentous bacteriophage a matsayin sabon maganin warkewa don maganin cutar Alzheimer”. Jaridar Cutar Alzheimer. 15 (2): 193–8. PMID 18953108.